E.r. Squibb & Sons, Inc.

Miguel A Ondetti

David W Cushman

Michael E Condon

Frank L Weisenborn

Sesha I Natarajan

Eric M Gordon

Denis E Ryono

Shih-jung Lan

Keith K Wong

Edward W Petrillo, Jr

Norma G Delaney

A K Aberg

Peter W Sprague

Patricia Ferrer

Sehsea I Natarajan

John Krapcho

Peter C Wade

Mark E McGovern

Henry Y Pan

Bernard Rubin

John T Sheehan

Aaron L Weiss

Charles Riffkin

Edward Condon

A method is provided for rehabilitating or restoring the vasorelaxant action of the endothelium impaired by atherosclerosis and/or hypercholesterolemia, thereby preventing arteriospasm in the coronary arteries using an angiotensin converting enzyme inhibitor such as captopril, fosinopril, ceranapril, enalapril or lisinopril, which may be administered by oral or parenteral dosage forms.

Method for rehabilitating the vasorelaxant action of the coronary

A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering an ACE inhibitor such as fosinopril or ceranapril, prior to, during and/or after angioplasty.

Method for preventing onset of restenosis after angioplasty employing an

A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering pravastatin alone or in combination with an ACE inhibitor such as captopril or ceranapril, prior to, during and/or after angioplasty.

Method for preventing onset of restenosis after angioplasty employing

A method is provided for slowing the progression of atherosclerosis in coronary arteries in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients in a mammalian species by administering an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.

Method for stabilizing or causing regression of atherosclerosis in

Acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.

Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene

Mercaptoalkanoyl and acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.

Use of enkephalinase inhibitors as analgesic agents

Enkephalinase inhibitors

New carboxymethyl esters of mercaptopropanoic acids, and salts thereof, have the formula ##STR1## wherein R is hydrogen or lower alkanoyl;

Carboxymethyl esters of mercaptopropanoic acids as enkephalinase

Antibacterial activity is exhibited by .beta.-lactams having a sulfate substituent in the 1-position and an acylamino substituent in the 3-position.

Antibacterial O-sulfated .beta.-lactam hydroxamic acids

The S-acylation of a mercaptoacyl amino acid having ACE inhibitory action with a diuretic containing a carboxyl group yields a product having both ACE inhibitory action and diuretic activity in vivo.

S-Acylation products of mercaptoacyl amino acids and carboxyl group

Compounds having the formula ##STR1## and salts thereof, wherein R.sub.1 is a readily hydrolyzable acyl protecting group;

4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and

Compounds for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprising angiotensin converting enzyme inhibitors selected from a group of mercaptoacyl aminoacids.

Compounds for alleviating angiotensin related hypertension

O-sulfated .beta.-lactam hydroxamic acids and intermediates

This invention is directed to compounds of the formula ##STR1## which are useful in the treatment of hypertension.

Mercaptoacyl derivatives of keto substituted pipecolic acid

This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.

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Princeton, NJ, United States of America

Miguel A Ondetti