Universidade De Santiago De Compostela

Servizo Galego De Saude (sergas)

Universidade Da Coruña

Endotherm Gmbh

Miguel A Maestro Saavedra

Antonio Mouriño Mosquera

Román Pérez Fernández

Borja Lopez Perez

Jose Esteban Castelao Fernandez

Rita Sigueiro Ponte

Samuel Seoane Ruzo

Pranjal Gogoi

Borja LÓPEZ PÉREZ

Antonio MOURIÑO Mosquera

Rita SIGÜEIRO Ponte

Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.

Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives

The present invention relates to compounds of pharmaceutical interest. More particularly, it relates to compounds of formula (I), to processes for obtaining thereof, to the intermediates of their synthesis and processes for obtaining the latter. The compounds of formula (I) have a certain affinity with the vitamin D receptor, they are active in a similar order to 1,25&#x3b1;-dihydroxyvitamin D(1,25D), with the advantage of producing less or no hypercalcemia.

Vitamin D analogues of pharmaceutical interest

Growing community of inventors

Santiago de Compostela, Spain

Miguel A Maestro Saavedra