Toray Industries, Inc.

Mie Kainoh

Toshiya Takahashi

Toshiaki Tanaka

Hiroyuki Meguro

Hajimu Kurumatani

Takeshi Ishigaki

Susumu Matsuda

Masayuki Kaneko

Nobuo Saito

Koji Taniguchi

Hideyuki Takeshige

Miyuki Funahashi

Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The spiro derivative according to the present invention has the chemical structure, for example, represented by the following Formula (31):

Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient

Cyclic peptides and medicinal use thereof

The present invention provides a protective agent for nervous system structural cells comprising a prostaglandin I derivative, preferably a prostaglandin I derivative, particularly beraplost, as an active component. This medicine exhibits excellent effects as a protective agent for nervous system structural cells, and is effective as an excellent agent for preventing or curing cerebrovascular disorder, cerebral nerve cell disorder, ischemic cerebral disorder, dementia, and peripheral nerve disorder due to diabetic or the like.

Protective agent for nervous system structural cells

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Fujisawa, Japan

Mie Kainoh