Japan Science and Technology Agency

Kyoto University

Nagoya City University

Mie Hata

Masaji Ishiguro

Gozoh Tsujimoto

Naoki Miyata

Takayoshi Suzuki

Akira Hirasawa

Yoshiyuki Takahara

Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; Rrepresents a Calkyl group or the like; Rrepresents a hydrogen atom, a Calkyl group or a Calkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or &#x2014;NR&#x2014; [wherein Rrepresents a hydrogen atom or a Calkyl group]. 

G-protein-conjugated receptor agonist

Growing community of inventors

Kyoto, Japan

Mie Hata