Chinese Academy of Sciences

Saint Louis University

Guangzhou Ribobio Co., Ltd.

Micky D Tortorella

Yanmei Zhang

Yican Wang

John Jeffrey Talley

Xin Lu

Yan Chen

Zhengchao Tu

Xiaorong Liu

Jianqi Liu

Mark G Obukowicz

Jing Min Xu

Ke Ding

Marvin Jay Meyers

Xiaoping Chen

John J Talley

Xiuqun Yang

Qiuyun Wang

Bill Biliang Zhang

Chuang He

Jiantong Guan

Zhe Wang

Yongjie Lin

Provided are siRNAs or chemically-modified siRNAs targeted against ADAMTS-5 or ADAM17 for inhibiting the expression of ADAMTS-5 or ADAM17. Use of the siRNAs for treating an ADAMTS-5 or ADAM17 associated disease, such as arthritis and other inflammation-related diseases, by injecting the siRNAs or preparations comprising the siRNAs into an articular cavity of the patient, are also provided.

Compositions and methods for inhibiting expression of ADAMTS-5 and ADAM17

Provided are a 4-sulfur pentafluoride phenol compound and a preparation method therefor, and a preparation method for a sulfur pentafluoride substituted benzopyran compound. According to the present invention, sulfur pentafluoride salicylaldehyde with multiple substituent groups is synthesized through a plurality of steps by using sulfur pentafluoride phenol as a raw material, and then the sulfur pentafluoride substituted benzopyran compound is synthesized on this basis. The method is simple and convenient, and low in cost; overcomes the defects that, at present, the number of types of sulfur pentafluoride phenols is small, and the synthesis of various sulfur pentafluoride substituted benzopyran compounds cannot be met; and has wide industrial application prospects.

4-sulfur pentafluoride phenol compound and preparation method therefor, and preparation method for sulfur pentafluoride substituted benzopyran compound

The present invention discloses deuterated benzopyran compounds having structure features as shown in Formula (I), or pharmaceutically acceptable salts or stereoisomers thereof, or prodrug molecules thereof. With excellent anti-inflammatory and analgesic effects and the capability to inhibit growth of tumor cells, such compounds are novel COX-2 selective inhibitors. The compounds and pharmaceutically acceptable salts thereof disclosed by the present application can be applied in preparing anti-inflammatory and analgesic drugs and drugs for treating or preventing tumors. 

Deuterated benzopyran compounds and the use in the treatment of pain and inflammation

Deuterated benzopyran compounds and application thereof

The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.

Compositions and methods for the treatment of malaria

Growing community of inventors

Guangdong, China

Micky D Tortorella