Tanabe Seiyaku Company, Limited

Michio Yamamura

Ryuichi Ishida

Hiroshi Sugano

Sumihiro Nomura

Koichiro Yamada

Mitsunori Gaino

Yasuhiko Sato

Takeshi Kanno

Keiichi Shintomi

There is disclosed a lactam derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group; R.sup.2 is a substituted or unsubstituted phenyl group, a cycloalkyl group or a nitrogen-containing 6-membered heterocyclic group; Z is oxygen atom or sulfur atom; and n is an integer of 2 or 3, and a salt thereof. The above lactam derivative is novel and useful as a pharmaceutical compound.

Lactam derivatives

Novel peptides of the formula: ##STR1## wherein R is hydrogen or a lower alkyl group, or a pharmaceutically acceptable salt thereof, and processes for preparing the same are disclosed. The peptides and pharmaceutically acceptable salts thereof are useful for the treatment of central nervous system disorders.

Novel peptides and processes for preparing the same

There are disclosed 1-methyl-4,5-dihydroorotyl-histidylprolinamide or a pharmaceutically acceptable acid addition salt thereof, processes for their preparation and pharmaceutical compositions containing them. The prolinamide and the pharmaceutically acceptable acid addition salts thereof are useful for the treatment of central nervous system disorder.

Dihydroorotic acid derivative and processes for preparing the same

A compound of the formula: ##STR1## wherein A is a group of the formula: ##STR2## R.sup.1 and R.sup.2 are the same or different and each hydrogen atom, nitro, amino, a protected amino, hydroxy or lower alkoxy,

Peptides and process for preparing the same

A piperazine derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkyl (C.sub.1-8), alkyl (C.sub.1-4)-sulfonyl or an acyl group of the formula: R.sup.3 CO--(wherein R.sup.3 is hydrogen, alkyl (C.sub.1-7), halogenoalkyl (C.sub.1-4), alkoxy (C.sub.1-4)-carbonyl-alkyl (C.sub.1-4), cycloalkyl (C.sub.3-6), alkenyl (C.sub.2-5), alkoxy (C.sub.1-4), amino, alkyl (C.sub.1-4)-amino or anilino), R.sup.2 is hydrogen, alkyl (C.sub.1-4), alkoxy (C.sub.1-4)-carbonyl-alkyl (C.sub.1-4), carboxy-alkyl (C.sub.1-4), alkenyl (C.sub.2-5) or alkyl (C.sub.1-4)-sulfonyl, or R.sup.1 and R.sup.2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C.sub.1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharmaceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressure-lowering activity. Said derivative also has a depressing effect on central nervous system.

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Tondabayashi, Japan

Michio Yamamura