Kaneka Corporation

Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

Kanaka Corporation

Michio Nomura

Eiji Ogino

Takashi Asahi

Yasuyoshi Ueda

Nobutaka Tani

Shuichi Kaneko

Takehiro Nishimoto

Osamu Odawara

Takamune Yasuda

Akito Sakai

Kenji Inoue

Kiyoshi Watanabe

Satomi Takahashi

Takehisa Ohashi

Shigeo Furuyoshi

Yukio Yamada

Fumiyasu Hirai

Yoshio Shimada

Takehiko Yamane

Takahisa Nakai

Yoshifumi Yanagita

Kazuhiko Yamada

Akira Matsumoto

Yuji Okubo

Yoshikazu Kogame

The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an immunoglobulin and/or an immune complex on a water-insoluble carrier, an adsorbent having remarkably excellent adsorption capacity may be obtained.

Peptide, novel adsorbent, adsorption unit and adsorption method

The present invention is to provide a purification method of obtaining N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine of high quality in good yield with high productivity, which is accordingly suited for commercial scale application. An impurity-contaminated N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine is crystallized from a mixed solvent of alcohol and water in a volume ratio of alcohol/water being 1 to 20 to remove a contaminating impurity into a mother liquor and give crystals of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine.

Purification method of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine

An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided. An adsorbent for removing hepatitis C virus which comprises a compound capable of adsorbing hepatitis C virus as immobilized on a water-insoluble carrier, an adsorption apparatus including said adsorbent, and an adsorbing method for removing HCV.

Adsorbent for eliminating hepatitis C virus, adsorber, and adsorption method

Immobilization of SH group-containing compounds on a solvent-insoluble support is carried out in the presence of an antioxidant to prevent oxidation of SH groups to S&mdash;S bonds. This improves immobilization efficiency and suppresses deterioration of inherent characteristics of the SH group-containing compound. Antioxidants include sodium pyrosulfite (sodium disulfite), sodium sulfite, sodium hydrogensulfite, sodium hydrosulfite and L-ascorbic acid. SH group-containing compounds include cysteine, peptides or proteins containing cysteine and thiol compounds such as ethanethiol, aminoethanethiol, benzylthiol and thiophenol. Preferably, the SH group-containing compound has a molecular weight not more than 3&times;10,. The support may be activated by a functional group such as glycidyl, imidocarbonato, tosyl, tresyl, carboxyl, amino, azido or hydroxyl. The support can be inorganic such as glass beads or organic such as a synthetic polymer or a polysaccharide.

Immobilization of SH group-containing compounds in the presence of a sulfite-containing antioxidant

Adsorbent for immunoglobulins and complexes thereof, adsorption method,

Adsorbent of interleukins, process for removing the same, and adsorber

Ethyl-.beta.-benzoyacrylate is reacted with an alkali metal salt of (S)-alanine or an alkali metal salt of N.sup.6 -trifluoroacetyl-L-lysine to form the corresponding Michael addition product, and not less than an equivalent amount of acid is added after completion of the Michael addition to prevent conversion of the (S,S) form of the product to the (R,S) form.

Process for preparing ethyl-alpha-amino-gamma-oxo-gamma-phenybutyrate

Growing community of inventors

Kakogawa, Japan

Michio Nomura