Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo

Hayashibara Co., Ltd.

Other

Kabushiki Kaisha Hayashibara Seibutsu

Michio Kubota

Toshio Miyake

Toshiyuki Sugimoto

Shigeharu Fukuda

Kazuhiko Maruta

Keiji Tsusaki

Tomoyuki Nishimoto

Hiroto Chaen

Tetsuya Nakada

Kazuyuki Oku

Hikaru Masahiro Watanabe

Takuo Yamamoto

Takanobu Higashiyama

Kazuko Hattori

Hajime Aga

Hitoshi Mitsuzumi

Kazuhisa Mukai

Shuzo Sakai

Tomohiko Sonoda

Shouji Ikegami

Hikaru Watanabe

Naohiko Katagiri

Yasuo Takeuchi

Sae Murai

Keiko Takeda

Hiromi Tatsukawa

Fujimi Tanabe

Shuzo Sakia

The object of the present invention is to provide a lipid-regulating agent or a composition for regulating the amount of lipids comprising the agent. The present invention solves the above object by providing a lipid-regulating agent comprising a cyclic tetrasaccharide and/or its saccharide-derivative(s) and a composition for regulating the amount of lipids comprising the lipid-regulating agent.

Lipid-regulating agent and use thereof

The object of the present invention is to provide a method and a process for producing 2-O-&#x3b1;-glucopyranosyl-L-ascorbic acid where 5-O-&#x3b1;-glucopyranosyl-L-ascorbic acid and 6-O-&#x3b1;-glucopyranosyl-L-ascorbic acid are not formed or formed in such a small amount that the formation of these can nor be detected. The present invention solves the above object by providing a process for producing 2-O-&#x3b1;-glucopyranosyl-L-ascorbic acid comprising the steps of allowing &#x3b1;-isomaltosyl glucosaccharide-forming enzyme together with or without cyclomaltodextrin glucanotransferase (EC 2.4.1.19) to act on a solution comprising L-ascorbic acid and, an &#x3b1;-glucosyl saccharide to form 2-O-&#x3b1;-glucopyranosyl-L-ascorbic acid and collecting the formed 2-O-&#x3b1;-glucopyranosyl-L-ascorbic acid.

Process for producing 2-O-alpha-D-glucopyranosyl-L-ascorbic acid

The present invention has objects to provide a method for inhibiting the formation of volatile aldehydes and/or the decomposition of fatty acids and use thereof. These objects are attained by establishing a method which comprises incorporating an &#x3b1;-oligoglucosyl &#x3b1;,&#x3b1;-trehalose(s) to a target product to inhibit the formation of volatile aldehydes per se and/or the decomposition of fatty acids per se in fatty acid-containing products; an inhibitory agent for inhibiting the formation of volatile aldehydes and/or the decomposition of fatty acids, which contains an &#x3b1;-oligoglucosyl &#x3b1;,&#x3b1;-trehalose(s) as an effective ingredient; and use thereof to thereby obtain various compositions such as food products, cosmetics, pharmaceuticals, and their materials and intermediates each having a high quality and stability.

Method of inhibiting formation of volatile aldehydes and/or decomposition of fatty acids and use thereof

A non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents, a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof are provided by use of an isocyclomaltooligosaccharide(s) having a structure represented by Formula 1,Cyclo{&#x2192;6)-[&#x3b1;-D-Glcp-(1&#x2192;4)]-&#x3b1;-D-Glcp-(1&#x2192;}, wherein 'is 4 or 5.

Isocyclomaltooligosaccharide(s), isocyclomaltooligosaccharide-forming enzyme, their preparation and uses

The present invention has an object to provide an accelerator for mineral absorption and a composition containing the accelerator. The object is solved by providing an accelerator for mineral absorption comprising cyclic tetrasaccharide and/or saccharide derivatives thereof and a composition containing the accelerator.

Accelerator for mineral absorption and use thereof

An object of the present invention is to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above object by providing a novel cyclic saccharide having a structure of cyclo{&#x3e;6)-&#x3b1;-D-glucopyranosyl-(1&#x3e;4)-&#x3b1;-D-glucopyranosyl-(1&#x3e;6)-&#x3b1;-D-glucopyranosyl-(1&#x3e;4)-&#x3b1;-D-glucopyranosyl-(1&#x3e;}, cyclic maltosylmaltose, novel cyclic maltosylmaltose-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the cyclic maltosylmaltose or a saccharide composition comprising the same, and uses thereof.

Cyclic maltosylmaltose, cyclic maltosymaltose-forming enzyme, their preparation and uses

The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and/or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of &#x3b1;,&#x3b1;-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.

Skin preparation for external use characterized by containing sugar derivative of &#x3b1;, &#x3b1;-trehalose

The object of the present invention is to provide an &#x3b1;-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an &#x3b1;-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the &#x3b1;-1,6 glucosidic linkage as a linkage at the non-reducing end and the &#x3b1;-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the &#x3b1;-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the &#x3b1;-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; &#x3b1;-isomaltosyl-transferring method using the enzyme; method for forming &#x3b1;-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-&#x3b1;-D-glucopyranosyl-(163)-&#x3b1;-D-glucopyranosyl-(166)-&#x3b1;-D-glucopyranosyl-(163)-&#x3b1;-D-glucopyranosyl-(16} using both the &#x3b1;-isomaltosylglucosaccharide-forming enzyme and the &#x3b1;-isomaltosyl-transferring enzyme; and the uses of the saccharides obtainable therewith.

&#x3b1;-isomaltosylglucosaccharide-forming enzyme, process and uses of the same

The object of the present invention is to provide a composition of metal ion compound whose inherent and unsatisfactory properties for its industrial application such as deliquescence, reducing power, oxidizing power, low solubility in water, etc., are improved; and their preparation and uses. The present invention solves the above object by providing an associate of trehalose or maltitol and a metal ion compound or bittern component, and their preparation and uses.

Association compound of trehalose or maltitol with metal ion compound

The present invention has objects to provide a method of inhibiting the 2,3-butanedione formation in order to produce a satisfactorily flavorful processed cacao bean product and an agent for inhibiting the 2,3-butanedione formation which is used for the method, and solves the above objects by providing a method of inhibiting the 2,3-butanedione formation during the process and/or preservation, and an agent for inhibiting the 2,3-butanedione formation which comprises one or more members selected from the group consisting of maltitol, &#x3b1;,&#x3b1;-trehalose and saccharide derivatives of &#x3b1;,&#x3b1;-trehalose as effective ingredients.

Method of inhibiting 2,3-butanedione formation from processed cacao bean product

The present invention have objects to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above objects by providing an isocyclomaltooligosaccharide(s) having a structure represented by General Formula 1, a novel isocyclomaltooligosaccharide-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the isocyclomaltooligosaccharide(s) or a saccharide composition comprising the same, and uses thereof.Cyclo{&#x2192;6)-[&#x3b1;-D-Glcp-(1&#x2192;4)]-&#x3b1;-D-Glcp-(1&#x2192;}&#x2003;&#x2003;General Formula 1(In General Formula 1, 'n' means a number of 4 or 5).

Isocyclomaltooligosaccharide (S) , isocyclomaltooligosaccharide-forming enzyme, their preparation and uses

A novel process for producing isomaltose and uses thereof and comprising the steps of contacting saccharides, which have a glucose polymerization degree of at least two and &#x3b1;-1,4 glucosidic linkage as a linkage at the non-reducing end, with an &#x3b1;-isomaltosylglucosaccharide-forming enzyme, in the presence or the absence of &#x3b1;-isomaltosyl-transferring enzyme to form a-isomaltosylglucosaccharides, which have a glucose polymerization degree of at least three, &#x3b1;-1,6 glucosidic linkage as a linkage at the non-reducing end, and &#x3b1;-1,4 glucosidic linkage as a linkage other than the non-reducing end, and/or to form cyclo{&#x2192;6)-&#x3b1;-D-glucopyranosyl-(1&#x2192;3)-&#x3b1;-D-glucopyranosyl-(1&#x2192;6)-&#x3b1;-D-glucopyranosyl-(1&#x2192;3)-&#x3b1;-D-glucopyranosyl-(1&#x2192;}; contacting the saccharides so formed with isomaltose-releasing enzyme to release isomaltose; and collecting the released isomaltose; and uses thereof.

Process for producing isomaltose and uses thereof

The present invention aims to provide a novel process for producing isomaltose and isomaltitol, and uses thereof, and it solves the object by establishing a process for producing isomaltose comprising a step of contacting a saccharide, having the &#x3b1;-1,4 glucosidic linkage as the linkage of non-reducing end and a glucose polymerization degree of at least two, with an &#x3b1;-isomaltosyl-transferring enzyme and an &#x3b1;-isomaltosylglucosaccharide-forming enzyme derived from a specific microorganism; a process for producing isomaltitol using the isomaltose produced by the above process; saccharide compositions comprising the isomaltose and/or the isomaltitol produced by the above processes; and uses thereof.

Processes for producing isomaltose and isomaltitol and use thereof

A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45&#xb0; C. but below 60&#xb0; C.; and an optimum pH in an acid pH range, i.e., a pH of less than 7. The two-types of enzymes can be obtained in a desired amount, for example, by culturing in a nutrient culture medium microorganisms capable of producing the enzymes or by recombinant DNA technology.

Growing community of inventors

Okayama, Japan

Michio Kubota