Seikagaku Corporation

Other

Fuji Photo Film Company, Limited

Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation)

Seikagaku Kogyo K.k.

Michinori Waki

Akiyoshi Matsumoto

Kenji Miyamoto

Naoki Yamamoto

Nobutaka Fujii

Yoshihiro Motani

The present invention provides a novel salt compound of a polypeptide represented by formula I and a transition metal which has high antiviral activity against human immunodeficiency virus (HIV).

Polypeptide transition metal salts and method of enhancing anti-HIV activity of polypeptide

The invention provides a cinnamic acid derivative having a novel spacer introduced into cinnamic acid which is photodimerizable, a cinnamic acid-polysaccharide derivative photocurable with high sensitivity and efficiency obtainable by introducing the above cinnamic acid derivative into a host polysaccharide such as a glycosaminoglycan, and a photocrosslinked cinnamic acid-polysaccharide derivative obtainable by exposing the same cinnamic acid-polysaccharide derivative to ultraviolet light irradiation.

Cinnamic acid derivative

Photocured cross-linked-hyaluronic acid gel and method of preparation

Polypeptide and anti-HIV agent prepared therefrom

A novel polypeptide sequence having the formula ##STR1## in which A.sub.1 is a hydrogen or at least one and no more than two amino acids selected from the group consisting of lysine and arginine,

Pharmaceutical compositions of lipopolysaccharide-binding polypeptides

A novel polypeptide sequence having the formula ##STR1## in which A.sub.1 is a hydrogen or at least one and no more than two amino acids selected from the group consisting of lysine and arginine, A.sub.2 is a tyrosine, phenylalanine or tryptophan residue, A.sub.3 is an arginine or lysine residue, A.sub.4 is at least one and no more than two amino acids selected from the group consisting of lysine and arginine, and A.sub.5 is an --OH or an NH.sub.2, is described. The polypeptide may be used in a pharmaceutical composition as an antimicrobial or antiviral agent, specifically as an anti-HIV agent.

Polypeptides with affinity to lipopolysaccharides and their uses

Growing community of inventors

Tokyo, Japan

Michinori Waki