Toyo Boseki Kabushiki Kaisha

National Institute of Advanced Industrial Science and Technology

Toyobo Co., Ltd.

Michiko Suzuki

Atsushi Sogabe

Shuhei Yamamoto

Masaru Kitagawa

Susumu Kashiwabara

Tomotake Morita

Hidenori Tanaka

Dai Kitamoto

Fumihiko Kajii

Tomohiro Imura

Makoto Ashiuchi

Tokuma Fukuoka

The present invention provides a nerve regeneration-inducing tube in which collagen having excellent adhesive property, cell growth property and differentiation inducing property to nerve cells is used as a scaffold for the nerve regeneration. The nerve regeneration-inducing tube is characterized in using the collagen which is made the concentration of sodium chloride contained therein not more than 2.0% by weight or, preferably, 0.1 to 1.5% by weight in a dry state. Purification of collagen is carried out by means of an isoelectric precipitation where the pH is 6.0 or higher and is lower than 10.0.

Nerve regeneration-inducing tube

There are provided a microorganism characterized by producing poly-&#x3b3;-L-glutamate with a molecular weight of 1,300,000 or greater and uniform optical purity under liquid culture conditions, a method of screening for the microorganism, a method of producing poly-&#x3b3;-L-glutamate having large molecular weight by using the microorganism, and poly-&#x3b3;-L-glutamate having an average molecular weight of 1,300,000 or greater. In addition, usages of these are provided.

&#x3b3;-L-PGA producing microorganism, method of producing &#x3b3;-L-PGA using the microorganism, crosslinked substance produced using the microorganism, and external dermal agent produced using the microorganism

The present invention includes as an active ingredient at least one biosurfactant, in particular mannosyl alditol lipid (such as MEL and MML) or triacylated mannosyl alditol lipid. This allows providing an activator and anti-aging agent that is excellent in activating and anti-aging effects on cells and that is safe enough to be used for a long time, and also providing cosmetics, quasi-drugs, drugs, and drinks and foods including the activator and the anti-aging agent as active ingredients. Further, the present invention provides MEL whose mannosyl erythritol skeleton in a molecular structure is 1-O-&#x3b2;-D-mannopyranosyl-meso-erythritol and a method for producing the MEL with use of a microorganism.

Activator including biosurfactant as active ingredient, mannosyl erythritol lipid, and production method thereof

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Otsu, Japan

Michiko Suzuki