La Jolla Cancer Research Foundation

Sanford-burnham Medical Research Institute

The Burnham Institute

Burnham Institute for Medical Research

Hamamatsu University School of Medicine

Other

Keio University

Fujita Academy

Michiko N Fukuda

Kazuhiro Sugihara

Minoru Fukuda

Daisuke Aoki

Shiro Nozawa

Naohiro Kanayama

Toshiaki Shibata

Motohiro Nonaka

Yuichiro Onodera

Naohira Kanayama

The present invention is a cytocidal agent including a peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 and a site selectively binding to a target molecule, in which the peptide consisting of an amino acid sequence represented by SEQ ID NO: 1 is a peptide exclusively consisting of L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to the 14amino acids are D-amino acids, and the 15to 19amino acids are L-amino acids, a peptide in which, in amino acid sequences represented by SEQ ID NO: 1, the first to 14amino acids are L-amino acids, and the 15to the 19amino acids are D-amino acids, or a peptide exclusively consisting of D-amino acids.

Cytocidal agent

Provided herein are compositions and methods for selectively targeting an endometriosis cell.

Endometriosis cell targeting peptide and uses thereof

The present invention relates to an agent for activating mammalian sperm and a method for activating sperm by use of the activating agent. More specifically, the present invention relates to a sperm activating agent containing endo-&#x3b2;-galactosidase and/or FGF, which accelerate motility of mammalian sperm, for use in in-vitro fertilization and artificial insemination by husband and a sperm activating method by adding endo-&#x3b2;-galactosidase and/or FGF.

Sperm activating agent and activating method using same

Disclosed are compositions and methods for selectively targeting an endometriosis cell. Also disclosed are compositions and methods for treating endometriosis.

Compositions and methods for targeted endometriosis treatment

Disclosed are conjugates comprising the annexin 1-binding peptide IFLLWQR covalently linked to a therapeutic or detectable agent. Also disclosed are compositions comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are isolated nucleic acids comprising a nucleic acid sequence encoding a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods comprising administering to a subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods of targeting a tumor cell in a subject comprising administering to the subject a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. Also disclosed are methods of targeting a tumor cell in a subject comprising administering to the subject a composition comprising a moiety and a peptide comprising an amino acid sequence that can bind to a carbohydrate receptor on a cell. The disclosed targeting is useful for treatment of, for example, cancer.

Methods and compositions related to annexin 1-binding compounds

Disclosed herein are compositions and methods useful for promoting sperm motility, promoting embryonic stem cell formation, promoting trophoblast formation, or promoting neuronal growth. The compositions and methods are based on peptide sequences that bind trophinin, inhibit bystin-mediated arrest of epidermal growth factor (EGF) receptor, and promotes EGF receptor autophosphorylation.

Trophinin-binding peptides and uses thereof

In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention peptides are useful to inhibit of the adhesion of cells containing particular cell-surface carbohydrates to cells containing cell-surface selectins. Also provided are pharmaceutical compositions comprising invention peptides useful in methods for inhibiting a carbohydrate from binding to a selectin, and in methods of inhibiting tumor cell metastasis in a subject.

Methods for inhibiting tumor metastasis, and peptides useful therefor

In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention peptides are useful to inhibit of the adhesion of cells containing particular cell-surface carbohydrates to cells containing cell-surface selecting. Also provided are pharmaceutical compositions comprising invention peptides useful in methods for inhibiting a carbohydrate from binding to a selectin, and in methods of inhibiting tumor cell metastasis in a subject.

Methods for inhibiting tumor metastasis, and peptides useful therfor

The present invention provides a method to prevent pregnancy in an individual by administering a trophinin vaccine, which can elicit an immune response in the individual administered the vaccine. The method utilizes mammalian trophinin and peptides derived thereof from human or mice. The method also utilizes a nucleic acid molecule encoding trophinin as the trophinin vaccine, which is expressed in the individual administered the vaccine. The nucleic acid molecule can further encode a trophinin-assisting protein that can be co-expressed with trophinin in the individual administered the vaccine. The invention also provides a method to prevent adhesion between a trophoblast cell and a uterine epithelial cell by administering a trophinin vaccine or peptides thereof. The invention further provides an adjuvant or a carrier protein to enhance the immune response to the trophinin vaccine. The invention also provides mammalian trophinin active fragments, antibodies to the fragments, nucleic acid molecules encoding the fragments and nucleic acid probes that can hybridize to the nucleic acid molecules.

Trophinin, trophinin-assisting proteins and methods to inhibit

The present invention provides substantially purified mammalian trophinin which can mediate cell adhesion. The invention also provides substantially purified trophinin-assisting proteins, which interact with trophinin to mediate cell adhesion. The invention further provides antibodies that are specifically reactive with trophinin or a trophinin-assisting protein. In addition, the invention provides active fragments of trophinin or trophinin-assisting proteins. The invention further provides a nucleic acid molecule encoding trophinin or a trophinin-assisting protein, vectors containing the nucleic acid molecules and host cells containing the vectors. The invention also provides a nucleotide sequence that can hybridize to a nucleic acid molecule encoding trophinin or a trophinin-assisting protein. The invention further provides methods to detect trophinin or a trophinin-assisting protein or a nucleic acid molecule encoding trophinin or a trophinin-assisting protein in a sample. The invention also provides methods of effecting cell adhesion by modifying cells to express trophinin or a trophinin-assisting protein. The invention further provides trophinin antagonists and methods to reduce or inhibit cell adhesion. The invention also provides methods to treat cells with trophinin agonists resulting in increased cell adhesion.

Trophinin and trophinin-assisting proteins

Trophinin and trophinin-assisting protein agonists, antibodies and

Trophinin and trophinin-assisting nucleic acids and methods of detection

The present invention provides substantially purified mammalian trophinin which can mediate cell adhesion. The invention also provides substantially purified trophinin-assisting proteins, which interact with trophinin to mediate cell adhesion. The invention also provides antibodies that are specifically reactive with trophinin or a trophinin-assisting protein. The invention further provides a nucleic acid molecule encoding trophinin or a trophinin-assisting protein, vectors containing the nucleic acid molecules and host cells containing the vectors. The invention also provides a nucleotide sequence that can hybridize to a nucleic acid molecule encoding trophinin or a trophinin-assisting protein. The invention further provides methods to detect trophinin or a trophinin-assisting protein or a nucleic acid molecule encoding trophinin or a trophinin-assisting protein in a sample. The invention also provides methods of effecting cell adhesion by modifying cells to express trophinin or a trophinin-assisting protein. The invention further provides trophinin antagonists and methods to reduce or inhibit cell adhesion. The method further provides methods to treat cells with trophinin agonists resulting in increased cell adhesion.

Growing community of inventors

San Diego, CA, United States of America

Michiko N Fukuda