Riken Corporation

Sumitomo Pharma Co., Ltd.

Michiko Mandai

Masayo Takahashi

Suguru Yamasaki

Hanako Ikeda

Fumitaka Osakada

An object of the present invention is to provide a cell population suitable for transplant of retinal tissue and a method of production thereof. The present invention provides a cell population for transplant, comprising retinal cells with a modified bipolar cell-regulating gene and a method of production thereof.

Human cell population comprising human retinal progenitor cells without an ISL1 gene for transplantation and methods of use thereof

A sphere-like cell aggregate according to one embodiment of the present invention comprises: a core part containing neural retina; and a covering part continuously or discontinuously covering at least a portion of a surface of the core part.

Cell aggregate including retinal tissue and production method therefor

The present invention provides a method of producing primate retinal progenitor cells, comprising culturing primate embryonic stem cells as suspended aggregates in a serum-free medium, and obtaining retinal progenitor cells from the culture. The present invention further provides a method of producing photoreceptor precursor cells, comprising culturing isolated retinal progenitor cells differentiated from embryonic stem cells, under adhesive conditions, in the presence of a gamma secretase inhibitor, and obtaining a photoreceptor precursor from the culture.

Growing community of inventors

Kobe, Japan

Michiko Mandai