Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Michiko Kosasa

Hachiro Sugimoto

Kiyomi Yamatsu

Atsuhiko Kubota

Yoshiharu Yamanishi

Norio Karibe

Atsushi Sasaki

Hiroo Ogura

Takashi Kosasa

Yutaka Tsuchiya

Shin Araki

Kunizou Higurashi

Youichi Iimura

Takayuki Hida

Kokichi Harada

Tomoko Sekiya

Toru Sawai

Eiki Takahashi

Takashi Seiki

Tohru Arai

Relaxin-3 is found to have feeding-stimulating activity, body weight increasing activity, and fat weight increasing activity when intracerebroventricularly administered to rats through observation of amount of feeding, body weight and fat weight after administration of relaxin-3. This invention includes: a polypeptide having useful effects in stimulating feeding, increasing body weight, and fattening; a therapeutic agent containing the polypeptide; a method of screening for a compound, a substance, or a salt thereof which activates or suppresses a receptor of the polypeptide; a kit for screening; and an agent with a substance which inhibits expression of the polypeptide, such as a feeding-suppressing agent, a therapeutic agent for the treatment of obesity, and a therapeutic agent for the treatment of diabetes.

Methods of affecting feeding and weight in mammals by administration of relaxin-3

A cyclic amine compound is defined by the formula: ##STR1## in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is --(CHR22) r--, R22 being H or methyl, --CO-- (CHR22)r--, .dbd.(CH--CH.dbd.CH)b--, .dbd.CH--(CH2)c-- or .dbd.(CH--CH)d.dbd. and the ring including T and Q is piperidine. The compound is useful to treat senile dementia.

Cyclic amine compounds and pharmaceutical use

A cyclic amine compound is defined by the formula: ##STR1## in which J is indanyl, indanonyl, indenyl, indenonyl, indanedionyl, tetralonyl, benzosuberonyl, indanolyl or a divalent group thereof, K is phenyl, an arylalkyl or cynnamyl, B is --(CHR22)r--, R22 being H or methyl, --CO--(CHR22)r--, .dbd.(CH--CH.dbd.CH)b--, .dbd.CH--(CH2)c-- or .dbd.(CH--CH)d.dbd. and the ring including T and Q is piperidine. The compound is useful to treat senile dementia.

Cyclic amine compounds with activity against acetylcholinesterase

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Tsukuba, Japan

Michiko Kosasa