Hiroshima University

Shionogi Company Limited

Toyo Advanced Technologies Co., Ltd.

Michihiro Hide

Kaori Ishii

Makiko Hiragun

Hidenori Suzuki

Shoji Mihara

Jens-M Schroeder

Takaaki Hiragun

Toshihiko Tanaka

Katsutoshi Yoshizato

Hidekatsu Yoneda

Akio Tanaka

Hajime Sato

Tomoko Tsutsui

Provided include a human IgE antibody that binds to a sweat allergy antigen protein and a human high-affinity IgE receptor but does not induce degranulation in a reaction with the sweat allergy antigen protein, and a composition for treatment or diagnosis of sweat allergy comprising the same.

Monoclonal IgE antibody that binds to sweat allergy antigen protein

Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.

Histamine releaser contained in human sweat

The invention relates to an antibody that inhibits histamine releasing activity induced by an antigenic substance contained in sweat. The invention further relates to an antibody which can react with a sweat antigen composition and inhibit the histamine releasing activity of the composition on a sweat antigen stimulation-responsive cell.

Anti-sweat antigen monoclonal antibody

An atopic dermatitis inducer binding to a human own IgE antibody and activating mast cells and basophiles, which includes a purified human secretion fraction, or an antigenic molecule or an antigenic determinant in the purified fraction, and obtained through the following steps of: filtering a human secretion, removing insoluble matters and collecting the filtrate; mixing the filtrate with a ConA-affinity carrier and collecting the supernatant; and separating a component having a histamine-releasing activity from the supernatant by column chromatography. This inducer is effective in diagnosing and treating human atopic dermatitis.

Atopic dermatitis inducer

The invention provides a method for evaluating the physiological activity of an external stimulus on living cells by means of a surface plasma resonance analyzer, which comprises evaluating the physiological activity of the external stimulus on the cells with an indication of a secondary signal appearing after a primary signal upon the exposure of the living cells to the external stimulus. According to the invention, the level of the physiological activity of an external stimulus on living cells can be evaluated accurately.

Method of evaluating cell activity

Growing community of inventors

Hiroshima, Japan

Michihiro Hide