Koito Manufacturing Company, Ltd.

Kyowa Hakko Kirin Co., Limited

Kyowa Kirin Co., Ltd.

Mitsubishi Denki Kabushiki Kaisha

Michihiko Suzuki

Kazuhiro Yamazaki

Fujihiko Sugiyama

Haruo Otani

Takeshi Kuboyama

Kimihisa Ueno

Arata Yanagisawa

Ryosuke Yasuda

Keisuke Yamamoto

Junichi Saito

Yuichi Takahashi

Tomoyuki Nishikawa

Tomohiro Tamura

Masayoshi Nakoji

Asana Makino

Hikaru Miyagi

Hidetsugu Asada

Taiji Oashi

Fumikazu Shinohara

Tomomi Murakami

Keiji Uehara

Kazuo Akiyama

Masahiro Matsubara

Takahiro Nakajima

Junichiro Yamamoto

Jun-ichi Saito

Fumihiko Sugiyama

So Iwata

Kozo Yao

Seiji Aratake

Yukihito Tsukumo

Akinori Yamamoto

Chiharu Matsunaga

Kazuki Hemmi

Kenichi Matsunaga

Tamaaki Sugiura

Akinori Hamaguchi

Yasuo Kouda

Takako Kouti

Yurika Hirano

Toru Okanuma

Hiroki Kosugi

Tetsuya Kataoka

An object of the present invention is to provide a method of enabling efficient structural analysis of a target protein that has been impossible or difficult to analyze so far, by stabilizing the target protein. The present invention provides an anti-BRIL antibody which specifically binds to BRIL or a BRIL fusion protein and an antigen-binding fragment thereof, a nucleic acid encoding the anti-BRIL antibody and the antigen-binding fragment thereof, a vector containing the nucleic acid, an antibody producing cell containing the vector, a method of producing the antibody, and a method of using the antibody in a protein structural analysis.

Anti-bril antibody

Methods of using an antibody to stabilize and analyze a BRIL fusion protein

An oligonucleotide having improved affinity for AGO2 is disclosed. The oligonucleotide has a nucleotide residue or a nucleoside residue represented by formula (I) wherein Xis an oxygen atom or the like, Ris formula (IIA), wherein Ris halogen or the like, and Ris a hydrogen atom or the like, or formula (IVA) wherein Yis a nitrogen atom or the like, and Yis CH or the like, or the like, Ris a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and Ris a hydrogen atom or the like at the 5' end thereof, and the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3. A method for improving the knockdown activity of an oligonucleotide wherein the oligonucleotide has a knockdown activity against an mRNA encoding a protein involved in a disease. 

Oligonucleotide

An oligonucleotide having a nucleotide residue or a nucleoside residue represented by formula (I) {wherein Xis an oxygen atom or the like, Ris formula (IIA) (wherein Ris halogen or the like, and Ris a hydrogen atom or the like), formula (IVA) (wherein Yis a nitrogen atom or the like, and Yis CH or the like), or the like, Ris a hydrogen atom, hydroxy, halogen, or optionally substituted lower alkoxy, and Ris a hydrogen atom or the like, or formula (VI) (wherein n2 is 1, 2 or 3)} at the 5' end thereof, wherein the nucleotide residue or the nucleoside residue binds to an adjacent nucleotide residue through the oxygen atom at position 3, is provided. 

Oligonucleotide having non-natural nucleotide at 5'-terminal thereof

A vehicle lampincludes a lamp body, a sealing material, and a lens memberand a leg portion. A groove portionis formed in the lamp body. The sealing materialis filled in the groove portion. The leg portionis provided on the lens member. The leg portionis inserted into the groove portionto thereby fix the lamp bodyand the lens membertogether via the seal material. A narrow portionis provided at a bottom side of the groove portionand a wide portionis provided at an openingside of the groove portion. A gap of the wide portionis wider than the gap of the narrow portion. The amount of sealing materialused in vehicle lampis limited while ensuring an easy assemblage.

Vehicle lamp

The invention provides a method of activating PPAR &#x3b3; and a method of treating or preventing a disease associated with PPAR &#x3b3; by administering a tricyclic compound having a PPAR &#x3b3; agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R-Rare the same or different and each represents hydrogen or the like, V represents a single bond or the like, Rand Rare the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like: 

Tricyclic compound

Provided is a tricyclic compound having a PPAR &#x3b3; agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R-Rare the same or different and each represents hydrogen or the like, V represents a single bond or the like, Rand Rare the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like: 

A lamp design surface member is provided. The lamp design surface member includes a design surface having a decorative surface. Concave-convex portions and planar portions are formed together on the decorative surface. The concave-convex portions have a peak cross-sectional height Rt of 1 &#x3bc;m or more and the planar portions have a peak cross-sectional height Rt smaller than 1 &#x3bc;m. The planar portions are formed so that an area ratio of the planar portions to the decorative surface is in a range of 30% to 80%.

Lamp design surface member and method of manufacturing lamp design surface member

The present invention provides a PPAR &#x3b3; agonist comprising, as an active ingredient, a tricyclic compound represented by the formula (I) (wherein Rrepresents lower alkyl optionally having substituent(s) or the like, Rand Rare the same or different and each represents lower alkyl optionally having substituent(s) or the like, Rand Rare the same or different and each represents a hydrogen atom or the like, Q-Q-Qrepresents CH&#x2550;CH&#x2014;CH&#x2550;CH or the like, Y represents a single bond or the like, Z-Zrepresents C&#x2550;CR(wherein Rrepresents a hydrogen atom or the like), or the like, and A represents &#x2014;COOH or the like), or a pharmaceutically acceptable salt thereof and the like.

Tricyclic compounds

A method of manufacturing a vehicle lamp includes providing a housing having a front opening and a transparent cover having a curved front face and a rear face having a welding face portion. The welding face portion of the transparent cover is placed in a closely contacting state with respect to the housing and the transparent cover is joined with the housing so as to close the front opening of the housing by irradiating a welding light ray toward the welding face portion through the transparent cover. The placing includes applying a pressing force against the housing to the transparent cover in a predetermined direction such that an angle of the welding face portion of the transparent cover with respect to the predetermined direction is closer to a right angle than an angle of the front face of the transparent cover corresponding to the welding surface with respect to the predetermined direction.

Vehicle lamp housing with transparent cover welded thereon, and method

A welding apparatus is provided with a lamp unit having a light source such as a halogen lamp and a multiple reflection surface. The light source applies incoherent electromagnetic waves that belong to a visible region and a near-infrared region in which a wavelength is 500 nm (nanometer) or more. The multiple reflection surface reflects and collects the light from the light source in the shape of a desired dot or line. The housing and the transparent cover are superimposed, and the light from the light source is collected by the multiple-reflection surface on the portion where the housing is superimposed on the transparent cover.

Welding apparatus and welding method

A vehicle lighting device manufacturing method, for joining a transparent cover with a housing ray welding, includes: a preliminary heating step of preparing welding portions of the transparent cover and the housing, and of forming, on part of the welding portion of the transparent cover and/or the housing, a built-up portion, which overlays a welding portion in a design, and heating and softening the built-up portion; a pressure-bonding step of pressure-bonding the welding portion of the transparent cover to the welding portion of the housing; and a welding step of welding the transparent cover and the housing that are pressure-bonded together by the emission of a light beam that irradiates the welding portion of the transparent cover and the housing along the entire length of edges.

Vehicle lighting device manufacturing method for positioning and welding a cover to a housing

A beam welding method in a vehicular lighting device where a transparent cover is mounted on a housing so as to cover its front face is characterized in that a transparent cover and a housing each includes a joining part. The method includes a step of integrating an elastic member with the joining part of the transparent cover, a step of bringing the elastic member into contact with the joining part of the housing, and a step of irradiating beams onto the joining part of the housing to weld the elastic member and the housing.

Vehicular lighting device and beam welding method

A vehicular headlamp includes a lamp body having an opening, a first reflector disposed within the lamp body, a lens, and a second reflector. The second reflector serves as an extension reflector to cover a gap between the opening of the lamp body and the first reflector. The lens and the second reflector are joined together at an edge portion thereof by laser welding. The second reflector has a leg portion on a back surface thereof. An edge portion of the opening has a groove to receive the leg portion, and seal material having a predetermined adhesibility, which can be pulled off, is injected into the groove. The second reflector joined to the lens is mounted on an edge of the opening of the lamp body via the seal material.

Vehicular lamp having a removable lens with an extension reflector

A vehicular lamp includes a lamp source, a lamp body accommodating the lamp source, and a lens attached to the lamp body. The lamp body has an abutment surface on the top portion of a peripheral wall, which is configured to rise in a direction of an optical axis of the light source along a peripheral edge of the lamp body. The abutment surface of the lamp body is configured to incline to the optical axis. Similary, the lens has an abutment surface corresponding to the abutment surface of the lamp body along a peripheral portion of the lens. In this case, the abutment surface of the lens is configured within the dimention of an outer surface of the lens so as not to protrude over the outer surface. The abutment surfaces of the lamp body and the lens are integrally jointed together by laser walding.

Vehicular lamp and method of manufacturing same

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Shizuoka, Japan

Michihiko Suzuki