Lifecycle Pharma A/s

Veloxis Pharmaceuticals A/s

Michiel Onne Elema

Per Holm

Birgitte Møllgaard

Jannie Egeskov Holm

Kirsten Schultz

Anders Buur

Birgitte Mullgaard

A process for the preparation of a particulate material by a controlled agglomeration method, i.e. a method that enables a controlled growth in particle size. The method is especially suitable for use in the preparation of pharmaceutical compositions containing a therapeutically and/or prophylactically active substance which has a relatively low aqueous solubility and/or which is subject to chemical decomposition. The process comprising i) spraying a first composition comprising a carrier, which has a melting point of about 5&#xb0; C. or more which is present in the first composition in liquid form, on a second composition comprising a material in solid form, the second composition having a temperature of at the most a temperature corresponding to the melting point of the carrier and/or the carrier composition and ii) mixing or others means of mechanical working the second composition onto which the first composition is sprayed to obtain the particulate material.

Controlled agglomeration

Growing community of inventors

Copenhagen, Denmark

Michiel Onne Elema