Alcresta Therapeutics, Inc.

Exxonmobil Research and Engineering Company

Estetra S.p.r.l.

Michiel Christian Alexander Van Vliet

David K Brown

Robert Gallotto

Kenneth Gary

Willem Robert Klaas Schoevaart

Edward S Park

Greta L Loring

Jihad Mohammed Dakka

Stuart Leon Soled

Sabato Miseo

Jose G Santiesteban

Herman Jan Tijmen Coelingh Bennink

Joseph Ernest Baumgartner

Johannes Jan Platteeuw

Roger Arthur Sheldon

David Widom

Albert Archie Stone

Franciscus Wilhelmus Petrus Damen

David J Brown

Willem Robert Klass Schoevaart

Embodiments of the disclosure are drawn to an enteral feeding device for hydrolyzing triglycerides in a nutritional formula. The device may include a body housing a chamber, an inlet configured to fluidly couple with a source of nutritional formula, and an outlet configured to fluidly couple with an enteral feeding tube. The device may include a headspace and a plurality of particles contained within the chamber, wherein the lipase is covalently bonded to the plurality of particles. The device may include an inlet filter located between the inlet and the chamber, wherein the inlet filter contains a first plurality of openings, and an outlet filter located between the chamber and the outlet, wherein the outlet filter has a second plurality of openings smaller than the plurality of particles.

Enteral feeding devices and related methods of use

The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3, 15a, 16a, 17&#x3b2;-tetraol (estetr-01), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10), 16-tetraene, wherein A is a protecting group and B is &#x2014;Si(R). The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10), 15-tetraen-17-one, in which A is a protecting group, via silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, and B is &#x2014;Si(R).

Process for the preparation of estetrol

Enteral feeding device and related methods of use

The present invention is related to a hydrocarbon oxidation process. The process comprises bringing one or more hydrocarbons into contact with a source of oxygen in the presence of a radical initiator and a catalyst. The catalyst comprises an organic metal complex located on a catalyst support, and is obtained by partial decomposition of the organic metal complex. For example, the process can be used to produce dimethyl carbonate from dimethoxy methane. The invention is also related to a partially decomposed catalyst that comprises a silica support and an organic metal complex, wherein at least 5% of the organic compound remains in the catalyst. The organic metal complex comprises an organic compound and a metal-based compound wherein the metal is selected from copper, nickel, and combinations thereof. The invention is also related to a process for manufacturing of a catalyst comprising mixing L-arginine, a Cu-based compound, water, and optionally another metal-based compound to form a solution; impregnating the solution onto a silica support to form a catalyst precursor; and partially decomposing the L-arginine to form the catalyst so that at least 5% of L-arginine remains in the catalyst.

Partially decomposed catalyst and hydrocarbon oxidation processes using the same

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Delft, Netherlands

Michiel Christian Alexander Van Vliet