Wisconsin Alumni Research Foundation

Michelle Renee Rondon

Jo E Handelsman

Robert M Goodman

Michael G Thomas

Elizabeth Anne Felnagle

Andrew David Berti

Provided are nucleic acid molecules comprising at least a functional fragment of the capreomycin biosynthetic gene cluster, polypeptides encoded by the cluster and recombinant host cells transformed with any of the nucleic acid molecules disclosed herein. Various methods using any of the vectors or expression cassettes that encode one or more of the gene products of the cluster are provided for heterologous production of capreomycin and capreomycin derivatives.

Heterologous production of capreomycin and generation of new capreomycin derivatives through metabolic engineering

The present invention provides methods and composition for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides compounds which can be identified by cloning biosynthetic pathways.

Microorganism genomics, compositions and methods related thereto

The present invention provides methods and compositions for accessing, in a generally unbaised manner, a diverse genetic pool for genes involved in biosynthetic pathways. The invention also provides compounds which can be identified by cloning biosynthetic pathways.

Growing community of inventors

Madison, WI, United States of America

Michelle Renee Rondon