Arsenal Biosciences, Inc.

Michelle Nguyen

Aaron Cooper

Anzhi Yao

Xinying Zheng

Somya Khare

Brendan Galvin

Katherine Harris

Natalie Bezman

Stephen Santoro

John Gagnon

Harbani Kaur Malik Chaudhry

Omar Khan

Adam Litterman

Nicole Allen

Jasper Williams

Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

Immune cells having co-expressed shRNAS and logic gate systems

Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

Safe harbor loci

Growing community of inventors

San Francisco, CA, United States of America

Michelle Nguyen