Scholar Rock, Inc.

Michelle Marie Straub

Nagesh K Mahanthappa

Thomas Schurpf

Adriana Donovan

Katherine Jane Turner

Justin W Jackson

Stefan Wawersik

Dong Yun Lee

William K McConaughy

Gregory John Carven

Kimberly Kafadar Long

Yung Chyung

Micah Webster

Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-β superfamily of proteins.

Compositions and methods for growth factor modulation

The present invention relates to antibodies that specifically bind pro-myostatin and/or latent myostatin, and methods and uses thereof.

Methods for altering body composition by administering anti-pro/latent myostatin antibodies

Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.

Compositions for making and using anti-Myostatin antibodies

Provided herein are proteins, antibodies, assays and methods useful for modulating growth factor levels and/or activities. In some embodiments, such growth factors are members of the TGF-&#x3b2; superfamily of proteins.

Methods for using anti-myostatin antibodies

Methods for making and using anti-myostatin antibodies

The present disclosure relates to the treatment of muscle conditions, such as SMA, with the use of an agent that inhibits myostatin signaling. The disclosure includes combination therapies that include a myostatin inhibitor and a neuronal corrector.

Use of myostatin inhibitors and combination therapies

Methods for inhibiting myostatin activation by administering anti-pro/latent myostatin antibodies

Anti-pro/latent-Myostatin antibodies and uses thereof

Anti-pro/latent-myostatin antibodies and uses thereof

Provided herein are antibodies that bind growth factor prodomain complexes, for example, growth factor prodomain complexes that include GDF-8 growth factor and GDF-8 prodomain. Also included are antibodies that bind growth factor prodomain complexes that have been altered by proteolytic processing.

Growing community of inventors

Brighton, MA, United States of America

Michelle Marie Straub