Mallinckrodt, Inc.

Other

Michelle M Jones

David H White

Mills T Kneller

Allan R Bailey

Thomas J Dunn

Narciso Ocampo Doran, Iii

Alexander N Petrov

Oliver Egan

Fiona Rooney

Strainer assembly

A process for the preparation of iosimenol comprising reacting 5,5'-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (C-VI) with a 3-halo-1,2-propanediol in an aqueous solvent. A process for the preparation of C-VI comprising reacting 3,3&#x2032;-[(1,3-dioxo-1,3-propanediyl)diimino]bis[5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride] (C-V) with 3-amino-1,2-propanediol in the presence of an inorganic base and a suitable non-aqueous polar solvent. A process for the preparation of C-V comprising reacting 3-amino-5-(aminocarbonyl)-2,4,6-triiodobenzoyl chloride (C-IV) with malonyl dichloride in a solvent comprising a suitable ester solvent, a suitable nitrile solvent or mixtures thereof.

Process for the preparation of iosimenol

Process for producing ioversol

The present invention discloses a new process for producing ioversol (marketed as OPTIRAY.RTM.) comprising:

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O'Fallon, MO, United States of America

Michelle M Jones