University of California

Other

Albert Einstein College of Medicine

Vtt Technical Research Centre of Finland Ltd

Fluxion Biosciences, Inc.

Novoheart International Limited

Michelle Khine

Joshua Keelyn Kim

Sun-Jun Park

Jonathan Pegan

Mark Bachman

Luke P Lee

Eugene Joseph Lee

Cristian Ionescu-Zanetti

Cheng-Wei Chen

Jolie McLane

Nicole Eckmann

Kimberly Veliz

Sophia Lin

Jeonggi Seo

Michael Schwartz

Francis G Duhay

David N Breslauer

Ronald Li

Matt Law

Sayantani Ghosh

Michael P Chu

Wendy Liu

Himanshu Sharma

Andrew Blatz

Tingting Wang

Michael David Brenowitz

Ronald A Li

Adrian Lau

Ralph Liedert

Joseph Garcia

Theron Frederick Lee Smith

Gregory Washington

David Dan Tran

Tang Wai Ronald Adolphus Li

Gareth Forde

Jolie McLane Nokes

Nicole Mendoza

Floranne Tavailau Ellington

Dorsey Ligon

Shreshta Jayadev

Eugene Lee

Chi-shuo Chen

Anthony Grimes

Michael Dunlap

Lancy Lin

Ajay Gopinathan

A platform configured to predict type or family of an unknown drug candidate compound, the platform including: a living cell or a tissue; a detector that measures an indicator of a cellular response by the living cell or tissue upon exposure to the unknown drug candidate compound; a memory configured to store data related to the indicator of the cellular response detected by the detector from a library of drug types and/or families; and one or more processing unit(s) configured to: process the data related to the indicator of the cellular response of the living cell or tissue upon exposure to the unknown drug candidate compound, and compare cellular response data from the library of drug types and/or families, so that a drug type and/or a drug family and/or a mechanism of action of the unknown drug candidate compound can be predicted on the basis of a similarity between the detected cellular response data of the unknown drug candidate compound and the cellular response data of the library of drug types and/or families. Also disclosed are methods of screening an unknown drug, including: comparing the data measured from a test cell to corresponding cellular response data in a library of known drug types, and determining a relationship between the unknown drug and a known drug type or a known drug family to predict the type or family of the unknown drug.

Methods and apparatuses for prediction of mechanism of activity of compounds

A method of estimating a continuous blood pressure waveform or a continuous blood pressure in a subject including: measuring an arterial blood pressure waveform or an arterial blood pressure with a sensor supported by a supporting structure comprising a polymeric substrate and connected to a processor and a transmitter, wherein the supporting structure is configured to press the sensor against a skin surface of a subject, wherein the sensor is configured to detect a biological metric of the subject, and wherein the processor is configured to quantify one or more signal(s) corresponding to the biological metric and the transmitter is configured to transmit the one or more signals to an external user system, and transforming the arterial blood pressure waveform or the arterial blood pressure to the continuous blood pressure waveform or the continuous blood pressure using a transfer function.

Vital signs monitor

Soft capacitive pressure sensors for continuous wearable health monitoring applications are described herein. Wrinkled gold thin films on elastomeric substrates are used as robust parallel plate electrodes to create a robust integration with the polymer, allowing repeated normal force to deform the thin film without failure. By incorporating micro-ridged structures that support the counter electrodes to create air cavities within the elastomeric dielectric layer, pressure sensitivity is further increased. The pressure sensors are configured to measure human physiological signals such as pressure exerted from a radial pulse on a skin's surface. The radial pulse pressure detected by the sensor can be correlated to an arterial blood pressure. Calibration of said pressure sensors using a neural network allows for determination of absolute blood pressure.

Soft capacitive pressure sensors

A mobile medical device for monitoring a respiratory condition in a subject, the medical device including: a sensor configured to be adhered to the skin of a patient, the sensor configured to yield a resistance signal that is modulated by movements of a chest of a patient during respiration; a sensor attachment module configured to receive the signal from the sensor and to output data to a mobile electronic device an indication of an adverse respiratory event. Also disclosed is a server for integrating data collected from a plurality of the mobile medical devices and a crowd-sourced respiration advisory system including a plurality of the mobile medical devices and a server for integrating data collected by the mobile medical devices.

Predictive respiratory monitor and system

A wearable sensor apparatus is disclosed that includes a flexible substrate adapted to be coupled with a skin surface of an expectant mother. A conductor is disposed on the flexible substrate. The conductor can include micron-scale invaginations. The conductor can be capable of repeatable variation in resistance when subject to a strain. Also disclosed is a system for monitoring the health of a fetus in utero that includes a wearable sensor apparatus. The wearable sensor apparatus is configured to output a signal responsive to an electrical input. The system includes a computing system with one or more hardware processors. The computing system is programmed to implement a signal processing module configured to access the output signal from the wearable strain gauge and generate an output indicative of health of the baby in utero. The output can be based in part on the received output signal and previously stored correlations between signal data from the wearable strain gauge and observations of the system or of the mother. A user interface module can be provided and can be configured to display an output indicative of health of the baby in utero.

Fetal health monitor

The disclosure relates to methods and devices for measuring samples, such as biological samples, especially those at low abundance, with high sensitivity and at low cost. A sample is disposed on a shrinkable scaffold and the shrinkable scaffold is shrunk, reducing the area where the sample is distributed, so as to effectively concentrate the sample on the surface of the scaffold. In the event that a biological sample is covalently attached to a scaffold having a silica structure, the increase in signal enhancement is also due to optical effects stemming from covalent linkage of the biological sample onto the silica structure of the scaffold. Silica (SiO) may be deposited onto a surface of a polymer film by functionalizing the surface of the polymer film to bind silica from a sol-gel solution, and coating the film with a sol-gel solution containing silica precursors, wherein solid silica from the sol-gel solution is deposited onto the surface of the polymer film. Also disclosed is an immunoassay platform comprising a silica-encapsulated first detection agent deposited on a polymer substrate.

Patterning silica islands onto thermoplastic shrink film

Provided are methods of preparing a sample for detection by placing the sample on a shrinkable scaffold and then shrinking the scaffold. An exemplary shrinkable scaffold is a thermoplastic substrate.

Detection of low concentration biological agents

An apparatus comprising a wearable device comprising a supporting structure, a sensor and an electronics module, wherein the supporting structure is configured to press the sensor against a skin surface of a subject, wherein the sensor is configured to detect a biological metric of the subject, and wherein the electronics module is configured to quantify and/or transmit one or more signal(s) corresponding to the biological metric. Some aspects relate to a method of monitoring a biological metric in a subject comprising: adorning a subject with the wearable device; and detecting the biological metric over a period of time in the subject with the wearable device. Other aspects relate to a method of treating a disease in a subject comprising: monitoring a biological metric in the subject over a period of time, and treating the subject with a therapeutic protocol, and monitoring the biological metric in the subject to assess treatment efficacy. Method are provided for estimating a central aortic pressure waveform in a subject comprising: measuring a radial artery pressure waveform in the subject and transforming the radial artery pressure waveform to a central aortic pressure waveform using a transfer function.

Described are fabrication methods of highly wrinkled metal thin films for applications in electronics such as wearable devices, strain sensors, and capacitive sensors.

Highly wrinkled metal thin films using lift-off layers

A method of making a sensor apparatus including placing a mask over a polymeric sheet, wherein the mask is configured to block regions of the polymeric sheet, depositing a conductive structure on the polymeric sheet at regions exposed through the mask, shrinking the polymeric sheet with conductive structure patterned on its surface by heating, and transferring the conductive structure to a flexible substrate.

Flexible sensor apparatus

Disclosed are methods of manufacturing a SH surface including: creating a master with SH features by: depositing a rigid material onto a first surface, wherein the first surface is a shrinkable platform; shrinking the first surface by heating to create a SH surface, wherein the SH surface has micro- and nano-scale structural features that trap air pockets and prevent water from wetting the surface; forming the master by molding an epoxy with the shrunken first surface having a SH surface, wherein the master acquires the SH features of the first surface; and imprinting the SH features of the master onto a second surface to impart the SH features of the master onto the second surface. Some embodiments relate to a superhydrophobic (SH) surface, an article including a SH surface as disclosed, such as a microfluidic device or a food container.

Scalable manufacturing of superhydrophobic structures in plastics

Provided are devices and methods of preparing a population of cardiomyocytes by aligning undifferentiated pluripotent cells on a nanosacale textured surface.

Engineered physical alignment of stem cell-derived cardiomyocytes

A sensor apparatus including a flexible substrate and a wrinkled conductor disposed on the flexible substrate. In some embodiments, the conductor includes micro-scale invaginations. Also disclosed are methods of making a sensor apparatus, including: placing a mask over a polymeric sheet, wherein the mask is configured to block regions of the polymeric sheet, depositing a conductive structure on the polymeric sheet at regions exposed through the mask, shrinking the polymeric sheet with conductive structure patterned on its surface by heating, and transferring the conductive structure to a flexible substrate. Also disclosed are methods of sensing a health condition of a user or patient. The methods include coupling a sensor apparatus to a surface of a user or patient overlying structures to be monitored. The sensor apparatus may include a crumpled conductor capable of detecting strain. Strain is detected by directing current through the sensor apparatus during flexing of the surface and measuring a characteristic of the sensor apparatus based on the strain to generate an output for a user, indicative of the condition of the user or patient.

This disclosure provides a monolithic mold including a plurality of lens forming features that can be used to simultaneously form a plurality of lenses with different sizes and shapes. The mold can be formed by disposing a polymeric material around a plurality of physical objects with different shapes and sized. A method of forming the mold includes providing a substrate that has a surface with regions of low and high wettability. Water is deposited on the surface such that water droplets are formed with different contact angles. The mold is formed around the droplets.

Method and kit for forming plastic lenses from molds formed on surface with varied wettability

Disclosed are hydroxyl radial generating devices, comprising: a substrate layer; and a pyrite layer configured to produce hydroxyl radicals. Another aspect relates to a method for producing a hydroxyl radical generating device, comprising: providing a polymeric substrate layer; placing a layer of pyrite on a surface of the polymeric substrate layer to form a multi-layer structure; and applying heat to the multi-layer structure such that at least the surface of the polymeric substrate layer contracts; wherein the layer of pyrite contracts to a lesser extent than the surface of the polymeric substrate layer providing a textured surface comprising the pyrite layer. Also disclosed is a method of analysis, comprising: placing a solution comprising a biological substance on a sample site of a hydroxyl generating device comprising a surface of pyrite; incubating the solution; and analyzing a sample including proteolytic fragments of the biological substance.

Pyrite shrink-film laminate as a hydroxyl radical generator

Growing community of inventors

Irvine, CA, United States of America

Michelle Khine