Pfizer Corporation

Michelle Bich Tran-Dubé

Jingrong Jean Cui

Robert Steven Kania

Hengmiao Cheng

Lei Jia

Mitchell David Nambu

Mason Alan Pairish

Hong Shen

Mary Catherine Johnson

Phuong Thi Quy Le

Jacqui Elizabeth Hoffman

This invention relates to polymorphs of (R)-3-[1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to compositions including such salts and polymorphs, and to methods of using such compositions in the treatment of abnormal cell growth in mammals, especially humans.

Polymorphs of a c-MET/HGFR inhibitor

The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.

Triazolopyrazine derivatives

Growing community of inventors

San Diego, CA, United States of America

Michelle Bich Tran-Dubé