Amgen Inc.

Michelle Akerman

Julio Cesar Medina

Jonathan B Houze

Liusheng Zhu

Zhihua Ma

Rajiv Sharma

Jiwen Liu

Yingcai Wang

Michael J Schmitt

Jinqian Liu

Wei Qiu

Jian Luo

Jian Zhang

Stephen J Shuttleworth

Daniel C H Lin

Ying Sun

Jeffrey D Reagan

Sean P Brown

Jinqain Liu

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ-L-P-L-M-X-L-Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders

The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formulaQ&#x2014;L&#x2014;P&#x2014;L&#x2014;M&#x2014;X&#x2014;L&#x2014;Awherein the definitions of the variables Q, L, P, L, M, X, Land A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables Q, L, L, M, X, L, and A are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.

Conformationally constrained 3-(4-hydroxy-phenyl)-substituted-propanoic acids useful for treating metabolic disorders

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San Francisco, CA, United States of America

Michelle Akerman