University of Cambridge

Lonza Biologics Plc

Wren Therapeutics Limited

Michele Vendruscolo

Christopher Martin Dobson

Jesus Zurdo

Fabrizio Chiti

Kateri Hayashi DuBay

Tuomas Pertti Jonathan Knowles

Tuomas Knowles

Jesús Zurdo

Pavan Kumar Challa

Christopher Dobson

Sean Chia

Johnny Habchi

Kai J Kohlhoff

Julius Bier Kirkegaard

Pietro Sormanni

Tadas Kartanas

Quentin Alexis Eric Peter

Michele Perni

The subject matter disclosed herein relates to methods of identifying pharmacophores and inhibitors against protein aggregation. The present disclosure also provides pharmacophores themselves and medical uses of agents in the treatment of diseases associated with protein aggregation.

Method of identifying novel protein aggregation inhibitors based on chemical kinetics

Method of tracking a plurality of objects comprising: focusing an image of the objects on an imaging element using an optical system; capturing the image of the objects using an imaging element comprising a plurality of pixels; measuring at least one characteristic of the objects from the captured image using an image processor; wherein the field of view is set be the widest field of view for which the image processor is able to measure the at least one characteristic.

Method of tracking a plurality of objects

The present invention provides methods of predicting protein aggregation and designing aggregation inhibitors. One such method for predicting potential protein aggregation inhibiting peptide sequences, includes the steps of: a) identifying a peptide sequence forming at least part of an aggregation region in a target protein; b) testing whether said peptide sequence forms part of a &#x3b2;-sheet; c) if a positive result is achieved in step b), extracting the adjacent strands of that sheet; d) identifying residues in the adjacent strands to said peptide sequence whose side chains interact with said peptide sequence, those residues forming a potential protein aggregation inhibiting peptide sequence. The present invention also provides methods of designing compounds using the residues identified in the above method; compounds produced by the methods and computer programs for carrying out the above methods.

Method for predicting protein aggregation and designing aggregation inhibitors

A method of determining aggregation rate data predicting an aggregation rate of a polypeptide defined by an amino acid sequence, the method comprising determining a hydrophobicity value, a charge value, and at least one shape propensity value for said sequence; identifying one or more aggregation-influencing patterns within said sequence; determining a pattern value for the sequence responsive to said identifying; and determining said aggregation rate data by determining a weighted combination of said hydrophobicity value, said charge value, said at least one shape propensity value, said pattern value and at least one factor extrinsic to said amino acid sequence.

Method and apparatus for assessing polypeptide aggregation

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Cambridgeshire, United Kingdom

Michele Vendruscolo