Dipharma Francis S.r.l.

Michele Scarpellini

Pietro Allegrini

Gabriele Razzetti

Sergio Riva

Paola Fassi

A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof wherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R,S) enantiomers, or a salt thereof, wherein Ris straight or branched C-Calkyl, optionally substituted with phenyl; (the asterisk * and R defined above), with a lipase from, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.

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Bergamo, Italy

Michele Scarpellini