Biochimica Opos Spa

Farmabios S.r.l.

Newchem S.p.a.

Biochimica Ops Spa

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Marco Da Col

Gianfranco Cainelli

Leone Dall'Asta

Mauro Panunzio

Achille Umani-Ronchi

Achille Umani Ronchi

Mauro Montorsi

Irene Resta

Alessandra Tolomelli

Sergio Sandri

Edoardo Mariani

Erika Andriolo

Stefano Rancan

Marco Bandini

A process for the preparation of Drospirenone (I) according to the scheme (A) wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing the formation of undesired side-products and is particularly convenient for industrial-scale manufacturing. 

Process for the preparation of drospirenone

Described herein is the isomerisation process of 6&bgr;-fluorosteroids into the corresponding pharmacologically active 6&agr;-fluoro derivatives, comprising the reaction of 6&bgr;-fluorosteroids, or 6&agr;/6&bgr; isomeric mixtures, with an organic base containing a diazoimino group in a suitable organic solvent.

Isomerisation of 6&bgr;-fluorosteroids into the corresponding 6&agr;-fluoro derivatives

The present invention refers to process for the preparation of a tiazoline-azetidinone of formula I ##STR1## which comprises N-protecting in position 1 of (3S,4S)-3-phenylace tamido-4-acetoxy-azetidin-2-one, converting the product thus obtained into the corresponding thioamide and subsequently ciclyzing and deprotecting.

Process for the preparation of a thiazoline-azetidinone

There is described the preparation of halogenated .beta.-lactam derivatives by introduction of a chlorine atom in the 3-position of the cephem nucleus starting from a 3-sulfonyloxycephem. Such starting materials are reacted with a chlorine ions donor in a basic medium.

Process for the preparation of halogenated .beta.-lactam compounds

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Bologna, Italy

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