University of Hawai'i

New York University

Institute for Cancer Research

Michele Carbone

Haining Yang

Harvey I Pass

Marco Emilio Bianchi

Joseph R Testa

Jianming Pei

Mitchell Cheung

Systems, methods, and computer readable media for diagnosing or characterizing a genetic predisposition to develop cancer are provided. Nucleic acids comprising a germline nucleic acid sequence encoding the BRCA1 associated protein 1 are sequenced or probed to determine if the nucleic acid sequence includes alterations that predispose a subject to develop cancer.

Methods for diagnosing a predisposition to develop cancer

Embodiments provided herewith relate to methods and compositions for treating or preventing cancer. More particularly, several embodiments are drawn to treating or preventing malignant mesothelioma with antagonists of high-mobility group box 1 (HMGB1).

Treatment and prevention of cancer with HMGB1 antagonists

Several embodiments provided herein relate to methods of diagnosing asbestos exposure or mesothelioma. Several embodiments also relate to methods of differentiating whether a tumor of the lung is lung cancer or mesothelioma.

Biomarker of asbestos exposure and mesothelioma

Growing community of inventors

Honolulu, HI, United States of America

Michele Carbone