University of California

Cornell University

The United States Government as Represented by the Department of Veterans Affairs

Fundacao Oswaldo Cruz-Fiocruz

Other

Novartis Ag

Michele Anne Barocchi

David A Haake

Lee W Riley

Albert I Ko

Julio Henrique Rosa Croda

Isadora Cristina Siqueira

James Matsunaga

Tracy Ann Young

Mitermayer Galvão Reis

Vega Masignani

Monica Moschioni

Paolo Ruggiero

Mitermayer Galvào Reis

Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.

Combinations of pneumococcal RrgB clades

The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in thesp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection withspecies that are capable of producing disease in humans and other mammals, including those of veterinary importance.

[object Object]

Growing community of inventors

Florence, Italy

Michele Anne Barocchi