Abbott Laboratories Corporation

Michele A Kaminski

Milan Bruncko

Fortuna Haviv

Lisa Marie Frey

Daryl Richard Sauer

Christopher R Dalton

Jonathan Greer

Bradley W Crawford

John T Randolph

Nicholas A Mort

Rolf E Swenson

Wesley J Dwight

John A DeMattei

Disclosed are 3&prime;,3&prime;-N-bis-desmethyl-3&prime;-N-cycloalkyl-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

3&prime;,3&prime;-N-bis-desmethyl-3&prime;-N-cycloalkyl erythromycin derivatives as LHRH antagonists

Tetrahydroisoquinoline derivatives of the formula: ##STR1## or a pharmaceutically acceptable salt, ester, or prodrug thereof, having activity as an LHRH antagonist, as well as pharmaceutical compositions containing the same, and methods for their use and preparation.

Tetrahydroisoquinoline derivatives as LHRH antagonists

Disclosed are 3',3'-N-bisdesmethyl-3',3'-N-bis-substituted-6-O-methyl-11-deoxy-11,12-cyc lic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

3',3-N-bis-substituted macrolide LHRH antagonists

Disclosed are 3'-N-desmethyl-3'-N-substituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

Macrolide LHRH antagonists

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Beach Park, IL, United States of America

Michele A Kaminski