Aviara Pharmaceuticals, Inc.

Michele A Benish

Ronald J Biediger

Robert V Market

Brandon M Young

Michael M Savage

Vincent A Boyd

Thomas P Thrash

Lindsay Bonner Hardy

Provided herein are compounds and pharmaceutical compositions of formula I where R, R, R, R, Rand Rare as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.

Propionic acid derivatives and methods of use thereof

Provided herein are methods for antagonizing the action of an &#x3b1;4-integrin to treat various pathophysiological conditions utilizing pharmaceutical compositions of compounds or pharmaceutically acceptable salts or stereoisomer(s) thereof of formula I where R, R, R, R, R, X and Rare as described herein.

Provided herein are compounds and pharmaceutical compositions of formula I where R, R, R, R, R, X and Rare as described herein. Also provided pharmaceutically acceptable salts or stereoisomer(s) of these compounds. In addition methods are provided for antagonizing the action of an &#x3b1;4-integrin to treat various pathophysiological conditions.

Growing community of inventors

The Woodlands, TX, United States of America

Michele A Benish