Medical Research Council

Rottapharm Biotech S.r.l.

Scuola Internazionale Superiore Di Studi Avanzati

Mrc Sissa-Scuola Internazionale Superiore De Studi Avanzati

Michela Visintin

Lucio C Rovati

Gianfranco Caselli

Antonino Cattaneo

Antonio Cattaneo

Riccardo Chiusaroli

Gabriele Ugolini

Wai-Choi Eric Tse

Terence Rabbits

Amos Maritan

Terrence Rabbitts

Giovanni Settanni

Tse Wai-Choi Eric

Terenos Rabbits

Lucio Claudio Rovati

Gianfranco Casellli

The present invention relates to an antibody, recombinant or synthetic antigen-binding fragments thereof able to recognize and bind an epitope comprised in the spacer domain of ADAMTS-5, nucleic acid and expression vector encoding the same, method of production and uses thereof.

Anti-ADAMTS-5 antibody, derivatives and uses thereof

The present invention relates to an antibody, recombinant or synthetic antigen-binding fragments thereof able to recognize and bind an epitope comprised in the TrkA amino acid sequence, medical uses thereof and a pharmaceutical composition comprising at least one of the above antibody, recombinant or synthetic antigen-binding fragments thereof.

Anti-TrkA antibodies, derivatives and uses thereof

A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This can be accomplished for many immunoglobulins expressed in yeast and/or in mammalian cells and allows the selection of immunoglobulins which are capable of functioning in an intracellular environment.

Selection of intracellular immunoglobulins

A method of identifying at least one consensus sequence for an intracellular antibody (ICS) comprising the steps of: creating a database comprising sequences of validated intracellular antibodies (VIDA database) and aligning the sequences of validated intracellular antibodies according to Kabat; determining the frequency with which a particular amino acid occurs in each of the positions of the aligned antibodies; selecting a frequency threshold value (LP or consensus threshold) in the range from 70% to 100%; identifying the positions of the alignment at which the frequency of a particular amino acid is greater than or equal to the LP value; and identifying the most frequent amino acid, in the position of said alignment.

Intracellular antibodies

Growing community of inventors

Trieste, Italy

Michela Visintin