Polichem S.a.

Michela Legora

Federico Mailland

Stefania Gagliardi

Daniela Ceriani

Simone Del Sordo

Giuliana Iob

A topical antifungal composition for treating onychomycosis includes a terbinafine and/or a pharmaceutically acceptable salt thereof in an amount of from 9% to 11% by weight of the composition, a hydroxypropyl chitosan in an amount of from 0.1% to 0.6% by weight of the composition, water in an amount of from 10.0% to 40.0% by weight of the composition, and a C-Calkanol in an amount of from 60% to 80% by weight of the composition.

Topical antifungal composition for treating onychomycosis

A nail lacquer consisting essentially of terbinafine as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvents, including a method for treating onychomycosis by topically administering such a nail lacquer to a patient in need of such a treatment.

Method of treating onychomycosis

The present invention provides secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested againstand. These compounds are active againstspecies such asand. 

Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents

The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested againstand. Many of these compounds are active againstspecies such asand. 

Secondary 8-hydroxyquinoline-7-carboxamide derivatives

New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed.  These compounds are useful as antifungal agents. Specifically, these compounds were tested againstand. These compounds are also active againstspecies such asand

Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof

The present invention is directed to a nail lacquer consisting essentially of terbinafine as an antimycotic agent, hydroxypropyl chitosan as film forming agent, water and a lower alkanol as solvents. The invention is also directed to a method for treating onychomycosis by topically administering such a nail lacquer to a patient in need of such a treatment.

A pharmaceutical formulation for the oral administration of cyclosporin is described, which formulation is capable of providing substantially constant and foreseeable plasma levels of the active ingredient. The formulation has the following quali-quantitative composition by weight:

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Appiano Gentile, Italy

Michela Legora