Merck Sharp + Dohme Corp.

Michela Bettati

Mark Stewart Chambers

David James Hallett

Ian Churcher

Helen Jane Szekeres

Michael Geoffrey Neil Russell

Philip Jones

Timothy Harrison

Leslie Joseph Street

Angus Murray MacLeod

William Robert Carling

Richard Thomas Lewis

Martin Richard Teall

Tamara Ladduwahetty

Kevin John Merchant

Simon Charles Goodacre

Paul Joseph Oakley

Peter Alan Hunt

Peter Blurton

Andrew S Jennings

Amanda Louise Boase

Adam Smith

Emmanuela Nizi

Victoria Alexandra Doughty

Abdul Quddus

Monique Bodil Van Neil

Leslie Jospeh Street

Jonathan David Wrigley

Dirk Beher

Compounds of formula I: are disclosed. The compounds are useful in treating or preventing diseases associated with deposition of A&#x3b2; in the brain.

(4, 5, 6, 7-tetrahydro-1-H-indol-7-yl) acetic acid derivatives for treatment of Alzheimer's disease

Compounds of Formula (I): inhibit the processing of APP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease. 

Gamma-secretase inhibitors

The compounds of formula I: inhibit gamma secretase and hence are of utility in the treatment or prevention of Alzheimer's Disease.

Pyrazole derivatives as gamma-secretase inhibitors useful in the treatment of Alzheimer's disease

A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a &#x2014;NH&#x2014; linkage, and substituted on the phenyl ring by one or two further substituents as defined herein, being selective ligands for GABAreceptors, in particular having good affinity for the &#x3b1;2 and/or &#x3b1;3 and/or &#x3b1;5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

Imidazo-triazine derivatives as ligands for gaba receptors

A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a &#x2014;NH&#x2014; linkage, being selective ligands for GABAreceptors, in particular having good affinity for the &#x3b1;2 and/or &#x3b1;3 and/or &#x3b1;5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

Imidazo-triazine derivatives as ligands for GABA receptors

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Sawbridgeworth, United Kingdom

Michela Bettati