Pharmaleads

Kos Therapeutics, Inc.

Iacta Pharmaceuticals, Inc.

Michel Wurm

Hervé Poras

Bernard P Roques

Marie Claude Fournie Zaluski

Stéphane Melik Parsadaniantz

Annabelle Reaux-Le Goazigo

Tanja Ouimet

The present invention concerns a pharmaceutically acceptable salt of a compound of the following formula (I): HN—CH(R)—CHS—S—CH—CH(R—CONH—CH(R)—COOR(I) and more particularly an acid addition salt thereof, and the compositions comprising the same, for use in the prevention or treatment of trigeminal nerve pain, in particular migraines or trigeminal neuralgia.

Amino acid derivatives containing a disulfanyl group as an inhibitor of NEP and APN for the prevention and treatment of trigeminal nerve pain

The present invention concerns a pharmaceutically acceptable salt of a compound of the following formula (I): HN&#x2014;CH(R)&#x2014;CHS&#x2014;S&#x2014;CH&#x2014;CH(R&#x2014;CONH&#x2014;CH(R)&#x2014;COOR(I) and more particularly an acid addition salt thereof, and the compositions comprising the same, for use in the prevention or treatment of trigeminal nerve pain, in particular migraines or trigeminal neuralgia.

Amino acid derivatives containing a disulfanyl group in the form of an NEP and APN inhibitor for the prevention and treatment of trigeminal nerve pain

The disclosure relates to compounds of formula (I): R1-NH&#x2014;CH(R2)-P(&#x2550;O)(OH)&#x2014;CH2-C(R3)(R4)-CONH&#x2014;C(R5)(R6)-COOR7, where R1 to R7 are as defined in the claims, for use of same in the treatment and/or prevention of ocular inflammation, and more particularly for improving the process of ocular healing. Thus, the compounds of formula (I) are used, in particular, to prevent neovascularisation, or to prevent or treat an ocular inflammation linked to a keratitis, scleritis, episcleritis, uveitis, cataract, synechia, macular oedema, detachment of the retina, ocular hypertension and degeneration of the optical nerve caused by glaucoma.

Aminophosphinic derivatives for preventing and treating eye inflammation

The disclosure relates to a method of treating or preventing eye pain in a subject in need thereof. The method includes administering a compound of formula (I), R&#x2014;NH&#x2014;CH(R)&#x2014;P(&#x2550;O)(OH)&#x2014;CH&#x2014;C(R)(R)&#x2014;CONH&#x2014;C(R)(R)&#x2014;COOR, to the subject.

Growing community of inventors

Royat, France

Michel Wurm