Science Union Et Cie

Adir Et Compagnie

Adir Et Cie

Adir

Science Union Et Cie, Societe Francaise De Recherche Medicale

Adir, S.a.r.l.

Adir Et Lie

Michel Vincent

Georges Remond

Michel Laubie

Bernard Portevin

Yolande Herve

Jean Lepagnol

Guillaume De Nanteuil

Bernard Marchand

Jean Baliarda

Jean-Claude Poignant

Jacques Bure

Claude Cudennec

Jacqueline Bonnet

Xavier B Pascaud

Armel Fradin

Christine Lila

Jean-Albert Boutin

Ghanem Atassi

Jacques Duhault

Emmanuel Canet

Michel Lonchampt

Catherine Biton

Michelle Boullanger

Compounds of formula (I): ##STR1## wherein: R.sub.1 represents an unsubstituted or substituted alkyl,

Peptides derived from trifluoromethylketones

Compound of formula (I): ##STR1## in which: R.sub.1 represents 1-adamantyl, dicyclopropylmethyl, substituted or unsubstituted (C.sub.3 -C.sub.6) cycloalkyl or substituted or unsubstituted bicyclo[2.2.2]oct-1-yl,

4-methyl-5-substituted-1,3-oxazoles having anti-inflammatory activity

Compound of formula (I): ##STR1## in which: R.sub.1 represents halogen, or hydroxy, alkyl, alkoxy, cyano, amino, mercapto, alkylthio or phenoxy,

1-phenylbicyclo[2.2.2]octane compounds

The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the nitrogen and carbon atoms to which it is bound, a heterocycle,

Nitrogen-containing bicyclic compounds and pharmaceutical compositions

The invention relates to a compound of formula (I): ##STR1## which can be used as N-myristoyltransferase inhibitors, in which R.sub.1 represents hydrogen, substituted or unsubstituted (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl, (C.sub.3 -C.sub.7) cycloalkyl methyl, substituted or unsubstituted (imidazolyl-2-yl)methyl, substituted or unsubstituted (indol-3-yl)methyl or (1-azaindolizin-2-yl)methyl,

N-myristoyl transferase inhibitors

The invention relates to compounds of formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is linked, cyclic amide as defined in the description,

Peptide compounds containing a cyclic amide structure

The invention relates to the use of N-myristoyl-(S)-phenylalanine in the treatment of diseases involving myristoylation such as cancer or AIDS. Medicinal products including N-myristoyl-(S)-phenylalanine which are effective for such purpose.

Use of N-myristoyl-(S)-phenylalanine for the treatment of diseases

The invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 represents a linear or branched, lower or higher alkoxy group or a substituted or unsubstituted amino group,

Substituted amino acid compounds

The invention relates to the compounds of general formula (I): ##STR1## in which: A represents, with the carbon and nitrogen atoms to which it is linked, a cycloamide group,

New heterocyclic tripeptide compounds

The invention relates to the compounds of general formula: ##STR1## in which: X denotes either an oxygen atom, or two hydrogen atoms;

Tripeptide compounds having a nitrogenous polycyclic structure

Tetrapeptide compounds of general formula: ##STR1## in which R denotes:

Peptide compounds having a nitrogenous polycyclic structure

Compounds of formula (I): ##STR1## in which E denotes a lower alkyl group, or preferably a hydrogen atom, and their addition salts with a pharmaceutically acceptable acid or base, the preparation thereof and pharmaceutical compositions containing them.

Anti-hypertensive substituted 2-azabicyclooctane-3-carboxylic acids

Process for the industrial synthesis of (2S,3 7aS)-2-carboxyperhydroindole by reduction of 2-carboxindole or of one of its esters to (R,S)-2-carboxyindo or of one of its esters which, after saponification, converted into the acid, the S isomer cf (R,S)-2-carboxyindoline being obtained by precipitation from the mixture of the two (R) and (S) isomers, in the presence of (+) methylbenzylamine, (S)-2-carboxyindoline being in its turn subjected to catalytic hydrogenation to give (2S, 3aS,7aS)-2-carboxyperhydroindole, after separation of (2S,3aR,7aR) isomer by crystallization. Application to the synthesis of carboxyalkyl d peptides capable of being employed in therapeutics.

Alpha-methyl benzyl amine salt of indoline -2- carboxylic acid

Process for the industrial synthesis of (2S, 3 7aS)-2-carboxyperhydroindole by reduction of 2-carbox indole or of one of its esters to (R,S)-2-carboxyindo or of one of its esters which, after saponification, converted into the acid, the S isomer cf (R,S)-2-carboxyindoline being obtained by precipitation from the mixture of the two (R) and (S) isomers, in the presence of (+) methylbenzylamine, (S)-2-carboxyindoline being in its turn subjected to catalytic hydrogenation to give (2S, 3aS,7aS)-2-carboxyperhydroindole, after separation of (2S,3aR,7aR) isomer by crystallization. Application to the synthesis of carboxyalkyl d peptides capable of being employed in therapeutics.

Growing community of inventors

Bagneux, France

Michel Vincent