Rhone-Poulenc Rorer S.a.

Farmalyoc

Michel Veillard

Gilles Spenlehauer

Christian Prud'Homme

Jean-Marc Bobee

Didier Bazile

Jean-Paul Michalon

Frederic Courteille

Guy Lebreton

Anne Coutel

Gilles Guerin

Guillaume Conrath

Anne Bousseau

Armand Frydman

Gabriel Gousset

Thierry Verrechia

Gilles Spenleuhauer

Michel Ponsot

Patrick De Lanty

Jean-Paul Plard

Biocompatible microspheres containing one or more active principals, a biodegradable and biocompatible polymer and a surface-active agent which is also biodegradable and biocompatible, contain less than 10 ppm of heavy metals. These microspheres are prepared by providing a solution of the polymer and of the active principal in a water-immiscible solvent which is more volatile than water and mixing with an aqueous solution of the surface-active agent, followed by evaporation of the solvent.

Microspheres, process for their preparation and their use

Nanoparticles are prepared by dissolving a poly(ethylene oxide) and/or poly(propylene oxide) polylactic copolymer in an organic solvent followed by formation of nanoparticles by mixing the solution containing the polymer with an aqueous solution and by precipitation, without using an additional colloidal protective agent or by microfluidization and solvent evaporation. Nanoparticles prepared by this method are disclosed.

Process for preparing nanoparticles

The invention discloses nanoparticles offering an extended time before capture by the reticulo-endothelial system. Said particles are composed of an ethylene and/or propylene polyoxide polylactic copolymer optionally mixed with a polylactic polymer.

Nanoparticles based on a polyoxyethelene and polyactic acid block

Stable, pharmaceutical ketoprofen salts for oral administration are provided in oily solutions to avoid direct contact of acid forms of ketoprofen with the gastric or duodenal mucus membranes. Sodium, arginine, lysine and/or N-methylglucamine salts of ketoprofen are disclosed in solutions of polyoxyethyenatide vegetable oil, castor oil, esters of fatty acids and/or polyols. These oily solutions of ketoprofen may be administered orally in capsule form.

Oily capsules of ketoprofen

Granulocyte colony-stimulating factor solution delivery method

Pharmaceutical compositions based on ebastine or analogues thereof

The present invention relates to new taxoid-based compositions consisting of solutions of these derivatives in a surface-active agent. These solutions are used for preparing perfusion solutions.

Taxoid-based compositions

This invention relates to new solid and porous single dosage form comprising beads and its preparation.

Solid and porous single dosage form comprising particles in the form of

New solid, porous unitary form comprising micro-particles and/or nano-particles, made by lyophilization are useful for the administration of therapeutically active substances, nutrition agents, diagnostic agents or cosmetic agents.

Solid porous unitary form comprising micro-particles and/or

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Sceaux, France

Michel Veillard