Centre National De La Recherche Scientifique

Université Des Sciences Et Technologies De Lille

Eurogentec S.a.

Universite De Sciences Et Techologies De Lille

Université De Lille

Université De Lille 1 - Sciences Et Technologies

Michel Salzet

Isabelle Fournier

Jean-Claude Edmond Tabet

Michel Dechamps

Maxence Wisztorski

Gottfried Proess

Rémi Lemaire

Benoit Fatou

Aurélle Tasiemski

Ivo Rudloff

Marc Lemaitre

Cristian Focsa

Aurélie Tasiemski

Michael Ziskind

Françoise Gaill

Rémi LeMaire

Michel Deschamps

Remi Lemaire

Edmond Jean-Claude Tabet

Benoît Fatou

The invention relates to a biological material molecular analysis device characterized in that it includes:&#x2014;a laser () optionally using an optical parametric oscillator (OPO), configured to emit a wavelength between 2.5 ym and 12 put, said configured laser () being intended to ablate said biological material by ejecting charged and/or uncharged particles;&#x2014;a mass spectrometer (); and&#x2014;a probe (S,) comprising at least one first analysis fiber (A,), connected to the laser (), and a transfer tube (T,), connected to the mass spectrometer ().

Device for real-time in vivo molecular analysis

Novel peptides having antimicrobial activity, and compositions containing the same.

Antimicrobial peptides

The invention concerns a method for determining at least one target molecule map in a tissue section, using at least one (A-X)n-B conjugate, wherein A is a tag molecule of known molecular weight, X is a linker that is cleaved during sample desorption/ionization, n is an integer of at least 1, and B is a binding molecule that binds specifically to said target molecule. When using MALDI mass spectrometry, said linker molecule X may be cleaved by photodissociation during sample laser irradiation if photocleavable at the wavelength of said MALDI laser. Alternatively, when using UV-MALDI, IR-MALDI, SIMS or DESI mass spectrometry, said linker molecule X may be cleaved by fragmentation during sample desorption/ionization.

Use of conjugates with linkers cleavable by photodissociation or fragmentation for mass spectrometry analysis of tissue sections

A method for preventing a break out of a neurodegenerative disease in an individual and for treating an individual suffering from a neurodegenerative disease comprising the administration of an effective amount of an antimicrobial and neurotrophic peptide.

Peptides having antimicrobial and neurotrophic activity and uses thereof

The invention concerns improved methods for studying peptides/proteins expression in a tissue section or for determining at least one compound, in particular a protein, expression map in a tissue section, using ionic MALDI matrices.

Use of ionic matrices for maldi mass spectrometry analysis of tissue sections

Growing community of inventors

Bourghelles, France

Michel Salzet