L'oreal

Institut National De La Sante Et De La Recherche Medicale

Michel Prunieras

Denis S Barritault

Michel Kermici

Yves Courtois

Isabelle Guedon Born Saglier

Cristina Arruti

Dominique Bernard

Francis Pruche

Method for diagnosing cellular aging or inflammation condition of

This biosensor comprises a membrane (8), in which an enzyme catalyzing the transformation of a substrate used in the cutaneous metabolism is immobilized, means for detecting and measuring a phenomenon caused by said transformation, which is representative of the concentration of the substrate to be measured, with said substrate being brought into contact with the enzymatic membrane (8), and a measuring cell (13), a wall area of which is formed by the membrane (8) and which is capable of being closed, during the measurement, by a cutaneous covering area (15), with the cell (13) being combined with means for making circulate therein a liquid for placing in solution the substrate to be measured. For the measurement, the biosensor is applied to the skin, the buffer is injected into the cell and, once said cell is filled, the detection and the measurement are carried out, then the buffer is again made to circulate in order to remove the solubilized substrate. This measuring cycle can be repeated without removing the electrode (1). The biosensor is used for measurement of cutaneous L-lactate with a Clark electrode combined with a membrane using L-lactate oxidase.

Method for the direct measurement of at least one chemical parameter of

A process for stimulating the growth of epidermis cells. The epidermis cells are contacted with an aqueous saline extract (RE) of ocular tissues. The process is especially applied for human epidermis cells. Application to the study of chromosomes of the human epidermis cell, particularly for the detection of natural or induced chromosome anomalies, and to the production of grafts, and especially autografts, usable on man, for example in the treatment of burns, cosmetic and diagnostic products.

Cosmetic compositions containing retinal extracts for increasing

Process for stimulating the growth of epidermal cells

Growing community of inventors

Paris, France

Michel Prunieras