Fovea Pharmaceuticals

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Assistance Publique-hopitaux De Paris

UniversitÉ Paris Descartes

Imagine Institut Des Maladies Genetiques Necker Enfants Malades

Centre Hospitalier National D'ophtalmologie Quinze-vingts

Foundation Ophtalmologiqueadolphe De Rothschild

Fondation Ophthalmologique Adolphe De Rothschild

Université Pierre Et Marie Curie

Michel Paques

Pierre Roy

Olivier Hermine

Yves Colin

Emmanuel Heron

Jean-Francois Girmens

Sarah Mrejen

Jean-François Girmens

The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.

Use of hydroxycarbamide for preventing retinal nonperfusion

The present technology relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and a guide operable to guide a needle into the interior of an eye, characterized in that it comprises means for displacing a superficial layer () of the eye over an underlying layer () of the eye as the plate is brought into contact with the eye before the needle is guided into the interior of the eye.

Apparatus for intra-ocular injection

The invention relates to an apparatus for injection into an eye comprising of a means for displacing a conjunctival layer of the eye over an underlying scleral layer of the eye so as to form a fold in the conjunctival layer, and means for guiding a needle through the conjunctival layer once the fold has been formed.

Apparatus for injection into an eye

The application relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and guiding means for guiding a needle into the interior of an eye, characterized in that the plate comprises a cut-out having an edge adapted to be positioned along the limbus delimiting the cornea and the sclera of the eye, so as to adjust the position of the guiding means with respect to the limbus.

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Paris, France

Michel Paques