Roussel Uclaf

Michel Mouren

Alain Jouquey

Gaetan Touyer

Jean Salmon

Jean-Pierre Demoute

Jean-Noel Veltz

Novel isomers or mixtures of isomers of radioactive pyrethrinoids marked with iodine of the formula ##STR1## wherein X.sub.1 is selected from the group consisting of halogen and --CF.sub.3, X.sub.2 is a halogen, R is the residue of an amino acid of the formula R--NH.sub.2 or a derivative thereof containing an iodine acceptor group and marked with iodine.sup.125 or iodine.sup.131, process for their preparation and intermediates and their use in radioimmunological determination.

Novel radioactive pyrethrinoids and use thereof

Novel radioactive estradienes labelled with tritium of the formula ##STR1## wherein .sup.3 H is tritium and R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 10 carbon atoms and the study and radioimmunological determination of non-radioactive 11.beta.-(4-dimethylaminophenyl)-17.alpha.-(prop-1-ynyl)-.DELTA..sup.4,9 -estradiene-17.beta.-ol-3-one and its metabolites in biological fluids and novel intermediates.

Novel radioactive estradienes

Novel radioactive estradienes labelled with iodine of the formula ##STR1## in the form of their syn or anti isomers or mixtures thereof wherein the wavy line indicates anti or syn position, R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 1 to 12 carbon atoms and R.sub.1 is the residue of an amino acid R.sub.1 NH.sub.2 possessing an iodine acceptor group or a derivative thereof labelled with iodine .sup.125 or .sup.131 and their preparation and novel intermediates, antigens prepared from the compounds of formula I and bovine seric albumin or human seric albumin and their preparation and their use for the preparation of antibodies.

Novel radioactive estradienes labelled with iodine

Novel radioactive .DELTA..sup.4,9,11 -estratrienes marked with iodine 125 or 131 having the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and acyl of an organic carboxylic acid of 2 to 12 carbon atoms, R.sub.1 is the reminder of an amino acid of the formula R.sub.1 NH.sub.2 or a derivative thereof being marked with iodine 125 or 131 and the wavy lines indicate the --OR is in the .alpha.- or .beta.-position and the oximido group is in the syn or anti position, a process and intermediates for their preparation, antigens prepared therefrom and use thereof to prepare antibodies.

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Michel Mouren