I.d.m. Immuno-designed Molecules

Centre National De La Recherche Scientifique

Parfums Christian Dior

Establishment Public Dit Centre National De La Recherche Scientifique

Michel Monsigny

Gerard Redziniak

Claudine Kieda

Patrick Midoux

Roger Mayer

Dominique Cerdan

Annie-Claude Roche-Degremont

Patrick Erbacher

Annie-Claude Roche

Pierre Perrier

Alain Denis

Nadia Sdiqui

Francois Daussin

Francis Delmotte

Pierre-Jean Lescanne

Polymeric complexes for the transfection of nucleic acids, with residues causing the destabilisation of cell membranes

The invention relates to compounds comprising one or several oligosides, each of said oligosides being fixed in a covalent manner on one or many molecules, matrixs or particles, specifically one, two or three, via an intermediary molecule possessing a nitrogen atom carried by a carbon in &agr; of a C&boxH;O group and one or many functional groups, specifically one, two or three, the covalent bond between said intermediary molecule and the oligoside being done by the intermediary of said nitrogen atom, and the covalent bond between said intermediary molecule and said molecule, said matrix, said particle, or said molecules, said matrixs, said particles being done by the intermediary of the said functional groups of said intermediary molecule and appropriate functional groups to the molecule(s), the matrix(ces) or the particle(s).

Derivatives of oligosides, their process of preparation and their applications

A compound consisting essentially of polylysine conjugated to non-charged residues and recognition signals wherein the free amino functions of said polylysine are substituted with non-charged residues and said recognition signals, which non-charged residues consist of gluconalactone and which recognition signals are at least one member of the group consisting of galactoside, mannoside, fucoside, Lewis.sup.x, Lewis.sup.b, oligomannoside, oligolactosamine saccharides and peptide ANP and said conjugated polylysine contains at least 30% unsubstituted free amino functions and a method of transfecting cultured cells.

Complexes of nucleic acid and polymer, their process of preparation and

The invention concerns a method of binding a product to the membrane of a melanocyte by means of a ligand-receptor bond, which comprises using a product consisting of a basic structure coupled to at least one ligand consisting of an oside residue accessible to the membrane receptors, said oside residue being a fucose residue, notably an Alpha-L-fucose residue.

Liposomal product with a ligand having fucose as a terminal moiety

The invention concerns a complex between at least one negatively charged nucleic acid and at least one positively charged polymeric conjugate, the link between the nucleic acid and the polymeric conjugate being electrostatic in nature, the polymeric conjugate containing a polymer formed from monomer components having free NH.sub.3.sup.+ functions of the aforementioned components and being as follows: --the free NH.sub.3.sup.+ functions from the aforementioned components are substituted in a ratio of at least 10%, advantageously from 45% to 70%, particularly 60%, by noncharged residues leading to a reduction of positive charges in comparison to the same nonsubstituted polymeric conjugate, facilitating the release of nucleic acid by the dissociation of the complex, --the aforementioned residues possess in addition the following properties:

Polylysine conjugates

Method of targeting melanocytes with a compound containing a fucose

Method of binding a product to the membrane of a keratinocyte by means

Macromolecular conjugates of muramylpeptides useful as a stimulant of the cellular immune systems have the formula (R--X).sub.m --(LAM) wherein R is an N-acetylmuramylpeptidyl group or a derivative thereof; (LAM) is a neoglycoprotein having affinity for macrophages or monocytes, consisting of a protein covalently substituted by more than five glycidic chains, each having at least five osidic units, X is a covalent bond between a functional group of the peptidic part of R and a functional group of (LAM) or X is the residue of a conventional bifunctional coupling agent capable of bonding to R and (LAM) by formation of covalent bonds; and m is a number greater than or equal to 1.

Muramylpeptide-glycoprotein immunostimulant derivatives, their

A prodrug comprises a polyhydroxylated polyamine to which a drug is linked by the intermediary of a peptidyl group. The prodrug is useful as an antitumor or antiparasite medicine.

Water soluble macromolecular prodrugs, their preparation and their use

Peptide derivatives of aminodrugs have longer lasting effects than the drugs without the peptide radical.

Water-soluble acylated derivatives of peptides or amino acids, their

Method for the fluorimetric determination of endotoxins, new peptides

Growing community of inventors

Saint-Cyr-en-Val, France

Michel Monsigny