Koninklijke Philips Corporation N.v.

Medtronic Bakken Research Center B.v.

Sapiens Steering Brain Stimulation B.v.

Signify Holding B.v.

Neuronexus Technologies, Inc.

Michel Marcel Jose Decre

Hubert Cecile Francois Martens

Hubert Cécile François Martens

Franciscus Paulus Maria Budzelaar

Michel Gerardus Pardoel

Martin Hillebrand Blees

Eugenio Cantatore

Marinus Josephus Jakobus Dona

Bartel Marinus Van De Sluis

Anthonie Hendrik Bergman

Stein Kuiper

Johannes Wilhelmus Weekamp

Youri Victorovitch Ponomarev

Paulus Cornelis Duineveld

Pieter Gerrit Blanken

Jeroen Herman Lammers

Gerwin Hermanus Gelinck

Evert Jan Van Loenen

David J Anderson

Jeroen Jacob Arnold Tol

Dirk Willem Harberts

Andreas Hubertus Montree

Peter Jan Slikkerveer

Jacobus Bernardus Giesbers

Egbertus Reinier Jacobs

Hubertus Maria Rene Cortenraad

Ronald Maarten Schneider

Johannes Cornelius Antonius Muller

Ke Wang

Marcus Franciscus Donker

Richard Joseph Marinus Schroeders

Dirkjan Bernhard Van Dam

Emil Toader

Thomas Pierre Cornil Duriez

Patrick Petrus Johannes Van Eerd

Teunis Johannes Antonius Heijmans

Christiaan Leonard Jozef Janssen

Jozef Elisabeth Franciscus Gootzen

Judith Margeet Rensen

Kevin Thomas Dolan

David James Anderson

In one example, a medical device system for at least one of delivery of electrical stimulation pulses or sensing of physiological signals, the system including an elongated carrier; and a thin film wound around the elongated carrier, wherein the thin film includes a plurality of electrical contacts, a plurality of electrodes located distal to the plurality of electrical contacts, and a plurality of conducting tracks, each of the plurality of conducting tracks providing an electrical connection between at least one of the plurality of electrodes and one of the plurality of electrical contacts, and wherein the thin film is wound around the elongated carrier from the distal end of the elongated film to the proximal end of the elongated thin film.

Lead and a system for medical applications

The invention relates to a method of monitoring a person () having an interest to an object. The method comprising steps of: () providing a data processor () for obtaining interaction data related to a remote interaction between the person and at least one of a plurality of the objects (), () using the data processor for analysis of the interaction data to identify a particular one of the objects (), to which the person has the interest, and () obtaining additional data related to the particular object for informing the person about the particular object. The analysis of the interaction data may comprise a step () of identifying a remote location where the interest of the person is focused, and a step () of determining locations of the objects with respect to the remote location.

Apparatus for monitoring a person having an interest to an object, and method thereof

A device for cranial implantation includes a ferrule and a plate for placement in the ferrule. Furthermore, a neurological implant system includes a probe and a device for cranial implantation.

Device for cranial implantation, and system and use thereof

A stimulation apparatus includes a stimulation lead (), a multiplexer (), a stimulation signal generator (), and a signal detector (). The stimulation lead () includes a plurality of stimulation electrodes () disposed in an array about a distal portion of the lead body (). The arrangement of the electrodes () facilitates the controlled steering of stimulating electrical field () in three dimensions. Four dimensional field steering may also be provided.

Tissue stimulation method and apparatus

The disclosure is directed to a deep brain stimulation (DBS) lead having a distal end for providing therapeutic electrical stimulation to tissue in a stimulation target area of a patient's brain, comprising an array of one or more stimulation elements and sensing elements located at the distal end of the lead. After the first implantation of the lead into the brain along a trajectory that is pre-determined by non-surgical procedures, the array of stimulation and sensing elements is capable of facilitating the location of the target area and the determination for each of the stimulation elements of the required stimulation parameters needed to provide the therapeutic stimulation to the brain tissue in the stimulation target area, without requiring any additional implantations of the lead after the first implantation.

First time right placement of a DBS lead

The disclosure is directed to a deep brain stimulation (DBS) lead having a distal end for providing therapeutic electrical stimulation to tissue in a stimulation target area of a patient's brain, comprising an array of one or more stimulation elements and sensing elements located at the distal end of the lead; each of the one or more stimulation elements is capable of providing electrical stimulation to the brain tissue in the target area; and each of the one or more sensing elements is capable of detecting electrical signals produced by nerve cells within the brain; wherein after the first implantation of the lead into the brain along a trajectory that is pre-determined by non-surgical procedures, the array of stimulation and sensing elements is capable of facilitating the location of the target area and the determination for each of the stimulation elements of the required stimulation parameters needed to provide the therapeutic stimulation to the brain tissue in the stimulation target area, without requiring any additional implantations of the lead after the first implantation. A stimulation system including the DBS lead and a pulse generator is disclosed. Also disclosed is a method of providing therapeutic DBS to brain tissue using the lead.

A neuromimetic device includes a feedforward pathway and a feedback pathway. The device operates in parallel with a suspect neural region, coupled between regions afferent and efferent to the suspect region. The device can be trained to mimic the suspect region while the region is still considered functional; and then replace the region once the region is considered dysfunctional. The device may be particularly useful in treating neuromotor issues such as Parkinson's disease.

Device for modulation of neural signals

The invention relates to a probe () for an implantable medical device. The probe has a distal end () and a proximal end (), and the probe () moreover comprises an electrode () at the distal end. The electrode is connected to a wire () extending from the electrode to the proximal end of the probe, where the resistivity of the wire is non-uniform along the length of the wire. The wire may have high resistivity at the distal end of the probe and low resistivity wires elsewhere. The high resistivity wires reduce the peak current density in the tissue of an implanted device, and thus prevents destructive heating and/or undesired stimulation of tissue during MRI examination. This highly contributes to MR safety which is a highly desired feature for these implantable electrical stimulation devices.

Probe for an implantable medical device

A method and a control system () are provided for determining a relation between stimulation settings for a brain stimulation probe () and a corresponding V-field. The brain stimulation probe () comprises multiple stimulation electrodes (). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (). The method comprises sequentially applying a test current to n stimulation electrodes (), n being a number between 2 and the number of stimulation electrodes () of the brain stimulation probe (), for each test current at one of the n stimulation electrodes (), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes () of the brain stimulation probe (), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (&#x3b7;)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.

Method and system for determining settings for deep brain stimulation

The invention relates to a preparing apparatus for preparing an influencing procedure for influencing a subject. The preparing apparatus () comprises a subject coil () for generating a magnetic resonance image of he subject (), an instrument guide device () for guiding an instrument () for influencing the subject (), a marker () being visible in the magnetic resonance image, and an attaching element for attaching the instrument guide device () to the subject coil () in a known spatial relationship. Since the spatial relationship between the instrument guide device () and the subject coil () is known, if they are attached to each other, a time consuming registration procedure for registering an influence trajectory, which has been planned based on the magnetic resonance image, and the instrument guide device () can be avoided.

Instrument guiding during magnetic resonance imaging

The invention relates to a neurostimulation system, particularly for deep brain stimulation (DBS), comprising a spatial array () of stimulation electrodes () and an associated controller (). The controller () is adapted to sequentially supply electrical pulses to different subsets of the stimulation electrodes (). Preferably, the controller () comprises a single pulse-generator () and a multiplexing unit () for distributing the pulses to different stimulation electrodes. The stimulation electrodes () may preferably be arranged on probes ().

Neurostimulation system having a controller for controlling the supply of electrical pulses

A system () comprising a box () for implanting in a mammal body part (), which box is provided with a first electrical contact (), and a module () for accommodating in the box, which module is provided with a second electrical contact () for cooperation with said first electrical contact. The first electrical contact and the second electrical contact are mutually movable, at least in a stationary accommodation of the module in the box, between a contact position in which said first and second electrical contacts are electrically connected, and a non-contact position in which said first and second electrical contacts are separated from each other.

System comprising a box for implanting in a body part

A pawn () for use on a board () is provided. The pawn () is arranged to provide a trigger signal upon a touch of a triggerable part of the pawn () by a user, and comprises communication means for communicating the trigger signal to a board (). The pawn () comprises at least two separate triggerable sub-parts () for, upon a touch of each respective one of the at least two separate triggerable sub-parts () by a user, respectively providing a first and a second trigger signal. The first and the second trigger signal are mutually distinguishable. Such a pawn () can easily be used for activating a certain function of a set of functions. A function is selected by touching a corresponding triggerable sub-part ().

Pawn with triggerable sub parts

A device () for transferring a pattern () from a stamp () to a substrate () comprises a table () for supporting a substrate (), a flexible stamp () and a movably arranged body () having a pressure chamber () for exerting pressure on a portion of the stamp (), so that the portion is pushed toward the substrate () and contacts the substrate (). During a pattern transferring process, the body () is moved. As a result, adjacent portions of the stamp () successively go through a process of being pushed toward the substrate (), getting in contact with the substrate (), and being allowed to move back in place again. In this way, it is achieved that the pattern () of the stamp () is transferred to the substrate (), without the introduction of vibrations, so that the transfer of the pattern () takes place in a highly accurate fashion.

Method and device for transferring a pattern from a stamp to a substrate

A system for manipulation of a body of fluid, in particular a fluid droplet comprises several control electrodes to which an adjustable voltage is applied to control displacement of the droplet on the basis of the electrowetting effect. There is a counter electrode having a fixed voltage between the body of fluid and one of the control electrodes. Further, as the counter electrode and the control electrodes are located at the same side of the fluid droplet, the fluid droplet is freely accessible at its side remote from the counter electrode and the control electrodes. Hence, the fluid droplet can be employed as an object carrier and a pay-load can be placed on the droplet from the freely accessible side.

System for manipulation of a body of fluid

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Eindhoven, Netherlands

Michel Marcel Jose Decre