Adir Et Compagnie

Adir Et Cie

Michel Lonchampt

Emmanuel Canet

Alain Dhainaut

Gilbert Regnier

Claude Guillonneau

Jacques DuHault

Guillaume De Nanteuil

Georges Remond

Michel Vincent

Bernard Portevin

Yves Rolland

Yolande Herve

Yves Charton

Jean-Luc Fauchere

Guillaume Poissonnet

Guy Lewin

Nathalie Kucharczyk-Gentric

Andre Tizot

Emmanuel Canft

New N-substituted cyclic amines of formula: ##STR1## wherein: X, R.sub.1, R.sub.2 and R are as defined in the description, their optical and geometric isomers and physiologically tolerable salts thereof. The compounds of the invention are powerful PDE4 inhibitors and can be used therapeutically.

N-substituted piperidines as PDE4 inhibitors

A compound of general formula (I): ##STR1## in which: R.sub.1 represents alkyl,

Flavone compounds

A compound of formula (I): ##STR1## wherein: R.sub.1 represents unsubstituted or substituted cycloalkyl, phenyl, naphthyl, heterocyclic, alkyl or alkenyl,

Substituted biphenyl compounds

A compound of formula (I): ##STR1## in which: R.sub.1 represents an indolyl, naphthyl, tetrahydronaphthyl, thienyl, phenyl, optionally substituted, or (C.sub.3 -C.sub.7)cycloalkyl group,

Pseudopeptides derived from neurokinins

The invention provides new compounds pertaining to the class of: aryl methoxy phenyl alkyl heterocyclic spiro compounds, enantiomers, diastereoisomers and physiologically-tolerable salts thereof. For example: 8-{2-�3-quinol-2-yl methoxy)phenyl!ethyl}-3,8-diaza-1-oxa-2-oxo spiro�4,5!decane is described. Medicinal products containing the same are useful in the treatment of any pathology involving modifications of leukotriene metabolism.

Heterocyclic spiro compounds

Compounds of formula (I): ##STR1## wherein: R.sub.1 represents an unsubstituted or substituted alkyl,

Peptides derived from trifluoromethylketones

New benzopyrrolidinone compounds, which can be used as medicaments and correspond to the formula ##STR1## in which: either: R.sub.1 and R.sub.2 together represent, with the bond of the etherocycle to which they are attached, an optionally substituted benzene nucleus and, simultaneously, R.sub.3 and R.sub.4 are hydrogen, (C.sub.1 -C.sub.4)alkyl or (C.sub.5 -C.sub.6)cycloalkyl; or:

Benzopyrrolidinone compounds as bronchospastic agents

Spiro (4,5) decane compounds of the formula: ##STR1## in which: X is methyl and

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Chevilly Larue, France

Michel Lonchampt