Agence Nationale De Valorisation De La Recherche (anvar)

Agence Nationale De Valorisation De La Recherche

Michel Level

Louis A Chedid

Pierre Lefrancier

Francoise Marguerite Audibert

Jean Choay

Monique Parant

Claude Carelli

Nigel Phillips

Jean-Marie Bernard

The invention relates to muramyleptide derivatives resulting essentially from the conjugation or the coupling, as the case may require, through an arm, between a muramylpeptide and a group containing two atoms contiguous with one another to each of which is attached a lipophile chain comprising from 8 to 100 carbon atoms, preferably from 14 to 24 carbon atoms. The derivatives according to the invention are endowed with remarkable stimulating properties with respect to the activation of macrophages, of which they amplify the tumoricidal properties.

Lipophile derivatives of muramylpeptides having properties of activating

The invention relates to an immunogenic principle containing a specific antigen determinant of a predetermined native antigen. This immunogenic principle is constituted by a conjugate between a hapten bearing said antigenic site and a muramyl-peptide, essentially in the absence of supporting macromolecules, this conjugate having an immunogenic effect not only against itself, but also with respect to the native antigen carrying said antigenic site.

Conjugates of haptenes and muramyl-peptides, endowed with immunogenic

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Paris, France

Michel Level