Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Commissariat a L'energie Atomique

Michel Leonetti

Alexandra Savatier

Jean-Claude Boulain

Adeline Gadzinski

Robert Thai

André Menez

Herve Volland

Alain Lecoq

Pascal Drevet

Patricia Lamourette

Evelyne Lajeunesse

Gervaise Moine

Anne Wijkhuisen

Hervé Volland

Céline Cousin

Culina Slobodan

The invention relates to a molecular complex for targeting the antigen towards cells comprising antigens, including at least one antigen associated with at least two ligands of surface molecules of cells comprising antigens, said complex including at least one first ligand of a sulphated sugar of the glycosaminoglycan family and a second ligand of a specific surface molecule of cells comprising antigens, and said first ligand being covalently bonded with said antigen and/or said second ligand.

Molecular complex for targeting antigens towards cells comprising antigens and uses thereof for vaccination

A method for the in vitro immunization of human B lymphocytes, comprising culturing a total mononuclear cell population of human peripheral blood in the presence of an antigenic composition comprising at least one antigen covalently bonded to both: (i) a Tat protein or a Tat fragment capable of oligomerization and (ii) a ligand of a surface molecule specific to the antigen presenting cells; a method for producing antigen-specific human antibodies derived from said in vitro immunization method.

Method for obtaining antigen-specific human antibodies by in vitro immunisation

The invention relates to a vaccine composition comprising at least one type of anti-HIV vaccine composition containing at least one type of stabilized Tat antigen and to the use thereof for preventing and/or treating a human HIV infection.

Stabilized Tat antigen and the use thereof for anti-HIV vaccination

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Nozay, France

Michel Leonetti