Delalande S.a.

Delande S.a.

A. H. Robins Company, Incorporated

Michel Langlois

Alain P Lacour

Philippe L Dostert

Patrick G Guerret

Jean-Francois R Ancher

Guy R Bourgery

Colette A Douzon

Bernard P Bucher

Alain J Renaud

Margherita Strolin-Benedetti

Phillippe L Dostert

Nicole A Dorme

Gisele C Mocquet

Mona M Ward

Robert J Naylor

Thierry F Imbert

Patrice Renaut

Gerard H Moinet

Brenda Naylor

Maryse F Masson

Jacky A Tisne-Versailles

Alain R Schoofs

Pierre-Andre PhSettembre

Christian R Jeanpetit

Pierre-Andre Ph Settembre

Alain-Rene Schoofs

Patrice J Capdevielle

Michel Maumy

Jean-Francois Rumigny

Maurice F Jalfre

Enantiomer of absolute configuration S of formula: ##STR1## where: X=O or S; and

Enantiomers of absolute configuration S of amide derivatives of

Compounds of general formula I ##STR1## wherein: X represents oxygen or sulphur; each of R.sup.1 and R.sup.3 independently represents hydrogen or a C.sub.1 -C.sub.4 alkyl group;

Anxiolytic-R-n(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides

The present invention relates to compounds of formula: ##STR1## in which: R.sub.3 is hydrogen, 2-tetrahydropyranyl or benzyl;

Derivatives of 1-[3-(4-hydroxyphenyl) 1-hydroxy 1-propyl] benzene

The present invention relates to compounds of formula: ##STR1## in which: R.sub.1 and R.sub.2 are such that:

Pharmaceutical or veterinary preparations containing (a) at least one compound with the formula: ##STR1## where:

Alkyl or benzyl phenol ethers, their preparation and their therapeutic

A mixture of the 4 stereoisomers of formula (I) below, each of the pairs of corresponding racemic diastereoisomers and each of the enantiomers corresponding to each pair, that is to say each of said stereoisomers: ##STR1## in which R.sub.1 represents: a hydrogen atom,

5-aminoethyloxazolidin-2-one derivatives

New derivatives of 3-amino quinuclidine of formula: ##STR1## in which X=sulfur or oxygen; R=H, lower alkyl or benzyl; and Ar=substituted phenyl or substituted pyrimidinyl. These new derivatives have utility in therapeutics as accelerators of the gastro-intestinal motor function and as medicament potentiators.

3-amino quinuclidine derivatives and the application thereof as

N-arylated oxazolidine-2-one derivatives corresponding to the formula: ##STR1## and of S(+) configuration, A representing in this case the hydroxyl radical or of R (+) configuration, A designating then the N-methylamino group, as well as the acid addition salts thereof. Application in therapeutics more particularly as monoamine oxidase inhibitors.

Optically active derivatives of N-arylated oxazolidine-2-one, the

New tetrazole derivatives, characterized in that they correspond to the formula: ##STR1## in which R.sub.1 represents: either a hydrogen atom in any one of the positions 1 to 5 of the tetrazole nucleus, R designating a branched alkyl group comprising at least 5 carbon atoms or a branched alkenyl group, or a methyl group in position 2(3) of the tetrazole nucleus, R representing the (1-propyl)n butyl chain. These new derivatives are useful as medicaments, more especially for their anti-epileptic action.

5-(1-Propyl)n-butyl tetrazoles

N-aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones are disclosed. These compounds possess antidepressant activity.

N-Substituted phenyl-5-aminomethyl oxazolidinones and their method of use

A compound of the formula ##STR1## where R is selected from the group consisting of CH.sub.3 --CO--(CH.sub.2).sub.2 --O--, ##STR2## The compounds are useful in treating depression.

-N-substituted phenyl-5-methoxymethyl-2-oxazolidinones and

Process for preparing a para-quinone or ortho-quinone derivative, possibly alkoxylated or aryloxylated, which consists in oxidizing respectively the corresponding hydroquinone or pyrocatechic derivative, by means of the complex prepared, in situ or separately, by combining a cuprous salt, a hydrocarbon substituted by a cyano group and molecular oxygen, the oxidation being possibly carried out in the presence of an alkoxylating or aryloxylating agent of the hydroxylated derivative type.

Process for preparing para-quinone or ortho-quinone derivatives,

Derivatives corresponding to the general formula: ##STR1## in which Ar represents a phenyl group; a phenyl group substituted by a halogen atom or by a trifluoromethyl group; or the (chloro-3 fluoro-4) phenyl group and n is either equal to zero or equal to 1 in which case X is a chain chosen from the following: --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 --O-- whose CH.sub.2 group is linked to Ar. These compounds are useful as medicaments more especially for the treatment of troubles of the central nervous system and senescence.

Aminomethyl-5 oxazolidinic derivatives and therapeutic use thereof

Method of treating the central nervous system troubles such as the Parkinson's disease and the senescence troubles, generally treated by the B type monoamine oxidase inhibitors, which comprises administering internally to a human being requiring such treatment a therapeutically effective amount of N-aryl 5-aminomethyl oxazolidine-2-one derivatives.

Therapeutical use of known 5-aminomethyl oxazolidine-2-one derivatives

There are disclosed piperidinio, piperazino and homopiperazino derivatives wherein there is N-substitution by a heterocyclic compound taken from the group benzimidazole, indole, purine or benzotriazole and to the organic or mineral acid addition salts of these derivatives. The process for preparation of such compounds and their use is also disclosed.

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Buc, France

Michel Langlois