Laboratoire Roger Bellon

Aventis Pharma S.a.

Michel Kryvenko

Michel Barreau

Philippe Girard

Guy Picaut

Michel Tabart

Jean-Luc Malleron

Arielle Genevois-Borella

Jean-Marc Paris

Sylvie Wentzler

Jean-Francois Desconclois

Jean-Fran&ccedil;ois Desconclois

Marc Pierre Lavergne

Auguste Techer

Marc-Pierre Lavergne

Eric Bacque

Marc P Lavergne

Benzo&lsqb;f&rsqb;naphthyridine derivatives, their preparation and compositions containing them

This invention relates to a novel 1,8 benzo[b]naphythyridine derivative of general formula (I), ##STR1## wherein R is H or a hydroxy, amino or alkylamino radical optionally substituted by amino or hydroxy, or R is dialkylamino of which the alkyl portions may form, with the nitrogen atom, a 5- or 6-membered heterocyclic ring which optionally contains a further heteroatom chosen from nitrogen, oxygen or sulphur, or R is C.sub.3-6 cycloalkylamino or an alkanylamino, N-alkyl N-alkanylamino or aminoalkylphenylamino radical; R.sub.1 and R.sub.2, which are the same or different, are in positions 2 and 3 and represent H, alkyl, C.sub.2-4 alkenyl, phenyl, or substituted phenyl, or R.sub.1 and R.sub.2 are in position 2 and represent alkyl; R.sub.3 is H or alkyl, fluoroalkyl, carboxyalkyl, C.sub.3-6 cycloalkyl, fluorophenyl, difluorophenyl, alkyloxy or alkylamino; and R.sub.4 is H or F, wherein the C.sub.1-4 alkanyl and alkyl radicals are linear or branched; stereoisomeric forms thereof or mixtures of these; and salts and hydrated forms thereof. These novel derivatives are useful as antimicrobials.

1,8 benzonaphthyridine derivatives and antimicrobial compositions

Oxazole derivatives, their preparation and pharmaceutical compositions

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Paris, France

Michel Kryvenko