Alza Corporation

Other

Durect Corporation

Michel J N Cormier

Peter E Daddona

Mahmoud Ameri

Yuh-Fun Maa

Robert M Gale

Felix T Theeuwes

Joseph Creagan Trautman

Wendy A Young

Armand P Neukermans

James Matriano

Wei-Qi Lin

WeiQi Lin

Richard L Keenan

Patricia S Campbell

Jay Douglas Audett

Marika Kamberi

Scott Sellers

Ahmad P Samiee

Paul B Foreman

Barry Block

Suneel K Gupta

Melinda K Nelson

Eric N Silverberg

Allison Luciano

Rama V Padmanabhan

Juanita A Johnson

Kofi Nyam

J Richard Gyory

Joseph B Phipps

Alfred A Amkraut

Thomas O Murdock

Philip W Ledger

Ivan W Chin

Wai-Loong Lim

Andrew I Poutiatine

Avtar S Nat

Hyunok Lynn Kim

Thomas M Stein

Jane Stepic

Cedric T Wright

Marika Kamberl

Andrew G Scott

Kellee Eng

Sara L Sendelbeck

Bruce P Edwards

Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

Stable therapeutic formulations

A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.

Transdermal nicotine salt delivery system

An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.

Apparatus and method for transdermal delivery of parathyroid hormone agents

The invention provides for a formulation for coating one or more microprojections which reduces or minimizes the loss of counterions from the coating in order to achieve a pH-stabilized formulation.

Formulations for coated microprojections containing non-volatile counterions

A device () and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (). The coating solution is applied to the skin piercing elements () using known coating techniques and then dried. The device () is applied to the skin of a living animal (e.g., a human), causing the microprotrusions () to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

Transdermal drug delivery devices having coated microprotrusions

A transdermal analgesic system having reduced potential for abuse, wherein the system provides for the controlled release of the antagonist at a rate sufficient to provide an abuse limiting release rate ratio of the antagonist to the analgesic when the dosage form is subject to abuse is disclosed.

Transdermal analgesic systems with reduced abuse potential

Apparatus for transdermal delivery of parathyroid hormone agents

The device including a plurality of stratum corneum-piercing microprojections, and a solid coating disposed upon the microprojections, wherein the solid coating includes at least one beneficial agent and a biocompatible carrier is provided. The device is applied to the skin of a living animal (e.g., a human), causing the microprojections to pierce the stratum corneum and deliver an effective dose of the agent to the animal.

Microprojection array having a beneficial agent containing coating

A method and device are described for applying a microprotrusion member () including a plurality of microprotrusions () to the stratum corneum with impact. The method and device are used to improve transport of an agent across the skin for agent delivery or sampling. The applicator () causes the microprotrusion member () to impact the stratum corneum with a certain amount of impact determined to effectively pierce the skin with the microprotrusions (). The preferred applicator () impacts the stratum corneum with the microprotrusion member () with an impact of at least 0.05 joules per cmof the microprotrusion member () in 10 msec or less.

Apparatus and method for piercing skin with microprotrusions

A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition

Growing community of inventors

Mountain View, CA, United States of America

Michel J N Cormier