L'oreal

Lvmh Recherche

Centre National De La Recherche Scientifique

Universitè De Montpellier

Loreal Sa

Lucas Meyer Cosmetics Canada Inc.

Institut Europeen De Biologie Cellulaire

Institut European De Biologie Cellulaire

Centre De Recherches Biologiques Et D'experimentations Cutanees

Institut European De Biologic Cellulaire

Institut Europeen De Biologie Cellulaiare

Universkin

Université De Montpellier I

Université Montpellier II

Michel Hocquaux

Bernard Jacquet

Quintino Gaetani

Michel Philippe

Georges Rosenbaum

Jean Baptiste Galey

Henri Sebag

Laurent Vidal

Patrice Andre

Francoise Estradier

Isabelle Renimel

Jacqueline Dumats

Anne-Marie Pinel

Jean P Laugier

Didier Dufetel

Céline Godenir

Eric Terranova

Didier Semeria

Remy Tuloup

Sylvie Genard

G&eacute;rard Malle

Agn&egrave;s Burande

Gerard Lang

Jean Cotteret

Alex M Junino

Serge Forestier

Jean R Maignan

Jean-Francois Grollier

Gerard Malle

Jean Martinez

Herve Andrean

Didier J Saint-Leger

Joanna Bakala

Albert Duranton

Gilles Subra

Estelle Loing

Khalid Bakkar

Jean L Leveque

Andre Rougier

Didier S Leger

Elian Lati

Agnes Burande

Philippe Bedos

Irina Beck

Stéphanie Almeida Épouse Scalvino

Didier Saint-Leqer

Claudine Masson

Anne-Marie Résidence Le Galoubet Pinel

The object of the present invention relates to a novel family of peptide conjugates of formula (I):A-X-X-Pro-Ala-X&#x2014;B&#x2003;&#x2003;(I)

Peptides of use in the preventive and curative treatment of alopecia

A compound of the formula I: R-A-Gly-His-B (I) wherein: A and B are independently of each other a L-lysine residue, a D-lysine residue, or a L- or D-lysine residue in which the NHgroup of the side chain comprises a modification, where-in said modification is (i) a replacement with a hydrogen, (ii) an acetylation, (iii) a benzoylation, or (iv) a palmitoylation; GIy is a glycine residue; His is a L- or D-histidine residue; R is CH&#x2014;(CH)&#x2014;CO&#x2014;, wherein n=2, 3, 4, 5, 6, 7 or 8; R' is a group of formula (II): N(Z)(Z&#x2032;) (II) wherein: Z and Z&#x2032; is hydrogen, a methyl group, an ethyl group, a phenyl group, an hexyl group, a decyl group or an hexadecyl group; or a racemate, an enantiomer or a diastereomer thereof, or mixtures thereof, or a salt thereof.

Compounds, use thereof in cosmetic and cosmeceutic applications, and compositions comprising same

Cosmetic compositions with anti-free radical activity have been developed. Such compositions preferably contain an association of at least the following three substances with anti-free radical activity: an extract of emblica, idebenone and N-acetylcysteine.

Cosmetic composition with anti-free radical activity

Cosmetic compositions with anti-free radical activity have been developed. Such compositions preferably contain an association of at least the following three substances with anti-free radical activity: idebenone; N-acetylcysteine, and alpha-tocotrienol or an ester thereof with a C-Corganic acid.

A cosmetic composition has an association of at least three of the following substances with anti-free radical activity, selected from: in which:R=a linear or branched, saturated or unsaturated C-Chydrocarbon chain; andR, Rand Rare identical or different and are a hydrogen atom or a methyl or methoxy radical,and its esters; The anti-free radical activity is greatly improved.

The invention relates to a peptide of formula W-DPhe-Arg-Z (I) and to a conjugate thereof of a formula A-W-DPhe-Arg-Z (II), wherein A is a radical corresponding to a monocarboxylic acid of general formula HOOC&#x2014;R (III), wherein R is an linear or branched possibly substituted by a hydroxy group aliphatic C-Cradical which can comprise one or several unsaturations, preferably from 1 to 6 unsaturations, a lipoic acid or the reduced form thereof, a dihydrolipoic acid, N-lipoyl-lysine or a phenylbutyric acid, W is His, Ala-His, Ala-Ala-His, Nle-Ala-His, DTrp-Ala-His, Nle-Trp-His, Lys, Ala-Lys, Nle-Ala-Lys, Orn, Ala-Orn, Nle-Ala-Orn, Ala, Nle-Ala-Ala, Arg, Ala-Arg. Nle-Ala-Arg, Nle-Ala-DTrp or a bond in case of compounds of formula (II), Z is NH, OH and OR, wherein R is a linear or branched aliphatic C-Cradical, TrpNH, NapNH, TpiNH, TicNH, AlaNH2TrpOH, NapOH, TpiOH, TicOH, AlaOH, PheNH, or PheOH, exempting a peptidic conjugate for which A is a radical corresponding to an acetic acid, W is Nle-Ala-His and Z is TrpNHin the form of enantiomers or diastereoisomer and the mixtures thereof including racemic mixtures. The use of the inventive compounds for cosmetically fighting against canities is also disclosed.

Peptides or peptidic conjugate derivatives of MSH and the use thereof for cosmetically fighting against canities

The invention relates to the use of peptidic conjugates containing Gly-His-Lys for producing dermatological or cosmetological compositions for stimulating hair growth or stopping hair fall.

Use of peptidic conjugates for preparing compositions for alopecia preventive and curative treatment

The invention relates to novel peptidic conjugates containing a Gly-His-Lys sequence and used for dermatology or cosmetology for stimulating hair growth or stopping hair fall.

Peptidic conjugates for alopecia prevention and treatment

The invention relates to novel compositions for the oxidation dyeing of keratin fibers, comprising at least one specific diaminopyrazole derivative, to the dyeing process using this composition, to novel diaminopyrazole derivatives and to a process for their preparation.

Composition for dyeing keratin fibers which contain at least one diaminopyrazole, dyeing process, novel diaminopyrazoles and process for their preparation

Use of cupric complex of 3,5-disopropylsalicylic acid by way of a cosmetic product and cosmetic compositions containing this compound for protecting the human epidermis against UV radiation

Composition for dyeing keratin fibers which contain at least one

Pyrrole derivatives of 1,4-naphthoquinone and of 1,4-dihydroxynaphthalene, dye compositions containing them and the corresponding dyeing process.

Pyrrole derivatives of 1,4-naphthoquinone and of

The present invention relates to the use of dehydroalanine derivatives of formula (I) ##STR1## with R.sub.1 : H or linear- or branched-chain C.sub.1 C.sub.4 alkyl, ##STR2## or linear- or branched-chain C.sub.1 -C.sub.20 alkyl where X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5 =H, halogen, hydroxyl, linear-or branched-chain C.sub.1 -C.sub.4 alkyl or alkoxy, ##STR3## and n=2, 3 or 4, for protecting the skin, the mucous membranes and/or the hair against oxidative stress and to the cosmetic and dermatological compositions containing such compounds and to new dehydroalanine derivatives.

Dehydroalanine derivatives for protecting the skin, the mucous membranes

Composition for slowing down the loss of hair and for inducing and stimulating its growth, comprising a compound of formula: ##STR1## in which: R.sub.1 and R.sub.2 denote H or an alkyl and do not simultaneously denote H;

Composition for slowing down the loss of hair based on pyrimidine

Growing community of inventors

Paris, France

Michel Hocquaux